Effects of oscillatory convective flow on chemical signal propagation in epithelia

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F12%3A43893661" target="_blank" >RIV/60461373:22340/12:43893661 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effects of oscillatory convective flow on chemical signal propagation in epithelia

Popis výsledku v původním jazyce

We study effects of convective transport on chemical signal propagation in a simple (single layer) epithelium by means of mathematical modeling. Oscillatory flow regimes were considered. In our model, we assume that the movement of an extracellular medium is affected by harmonically oscillating convective flow. The oscillatory flow can be induced by heart action or walking. We have carried out numerical simulations using Comsol Multiphysics 3.5. Our results suggest that the signal propagation velocity increases with increasing amplitude, if the convective velocity harmonically oscillates around the zero value. The dimensionless propagation velocity also depends on the period. At lower period regimes, the velocity is almost the same as in the case withstagnant extracellular medium (with zero convective velocity). With longer periods, the velocity becomes significantly higher. These results were confirmed by independent simulations based on the finite difference method.

Název v anglickém jazyce

Effects of oscillatory convective flow on chemical signal propagation in epithelia

Popis výsledku anglicky

We study effects of convective transport on chemical signal propagation in a simple (single layer) epithelium by means of mathematical modeling. Oscillatory flow regimes were considered. In our model, we assume that the movement of an extracellular medium is affected by harmonically oscillating convective flow. The oscillatory flow can be induced by heart action or walking. We have carried out numerical simulations using Comsol Multiphysics 3.5. Our results suggest that the signal propagation velocity increases with increasing amplitude, if the convective velocity harmonically oscillates around the zero value. The dimensionless propagation velocity also depends on the period. At lower period regimes, the velocity is almost the same as in the case withstagnant extracellular medium (with zero convective velocity). With longer periods, the velocity becomes significantly higher. These results were confirmed by independent simulations based on the finite difference method.

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/ME10036" target="_blank" >ME10036: Vliv konvektivního toku na šíření chemického signálu v živých tkáních</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

2012 AIChE Annual Meeting

ISBN

978-0-8169-1073-1

ISSN

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e-ISSN

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Počet stran výsledku

6

Strana od-do

1-6

Název nakladatele

American Institute of Chemical Engineers by Omnipress

Místo vydání

New York

Místo konání akce

Pittsburgh

Datum konání akce

28. 10. 2012

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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