Oscillatory Flow Accelerates Autocrine Signaling due to Nonlinear Effect of Convection on Receptor-Related Actions

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895776" target="_blank" >RIV/60461373:22340/13:43895776 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.sciencedirect.com/science/article/pii/S0006349513007054" target="_blank" >http://www.sciencedirect.com/science/article/pii/S0006349513007054</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.bpj.2013.06.026" target="_blank" >10.1016/j.bpj.2013.06.026</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Oscillatory Flow Accelerates Autocrine Signaling due to Nonlinear Effect of Convection on Receptor-Related Actions

Popis výsledku v původním jazyce

We study effects of oscillatory convective flow in extracellular space on the velocity of chemical signal propagation having a form of a front wave above a cellular layer. We found that the time-averaged propagation velocity under oscillatory flow for aparticular Peclet number amplitude is slower than the velocity under steady laminar flow regime for the same value of the Peclet number, but significantly faster than under no-flow conditions. We derive asymptotic values of the propagation velocity and asymptotic characteristics of the corresponding concentration fronts in high- and low-frequency regimes and show that the reason for the observed velocity increase under the oscillatory flow stems from a nonlinear dependence of the propagation velocity onthe Peclet number, particularly from the convex character of the dependence. Our findings suggest that the specific responses of cellular cultures to different flow conditions in the extracellular space (for example, expression of athero

Název v anglickém jazyce

Oscillatory Flow Accelerates Autocrine Signaling due to Nonlinear Effect of Convection on Receptor-Related Actions

Popis výsledku anglicky

We study effects of oscillatory convective flow in extracellular space on the velocity of chemical signal propagation having a form of a front wave above a cellular layer. We found that the time-averaged propagation velocity under oscillatory flow for aparticular Peclet number amplitude is slower than the velocity under steady laminar flow regime for the same value of the Peclet number, but significantly faster than under no-flow conditions. We derive asymptotic values of the propagation velocity and asymptotic characteristics of the corresponding concentration fronts in high- and low-frequency regimes and show that the reason for the observed velocity increase under the oscillatory flow stems from a nonlinear dependence of the propagation velocity onthe Peclet number, particularly from the convex character of the dependence. Our findings suggest that the specific responses of cellular cultures to different flow conditions in the extracellular space (for example, expression of athero

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/ME10036" target="_blank" >ME10036: Vliv konvektivního toku na šíření chemického signálu v živých tkáních</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

BIOPHYSICAL JOURNAL

ISSN

0006-3495

e-ISSN

—

Svazek periodika

105

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

818-828

Kód UT WoS článku

000323141100031

EID výsledku v databázi Scopus

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