Nonaqueous Capillary Electrophoretic Enantioseparation of Water Insoluble Troger's Base Derivatives Using beta-Cyclodextrin as Chiral Selector

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895230" target="_blank" >RIV/60461373:22340/13:43895230 - isvavai.cz</a>

Výsledek na webu

<a href="http://onlinelibrary.wiley.com/doi/10.1002/chir.22220/abstract" target="_blank" >http://onlinelibrary.wiley.com/doi/10.1002/chir.22220/abstract</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chir.22220" target="_blank" >10.1002/chir.22220</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Nonaqueous Capillary Electrophoretic Enantioseparation of Water Insoluble Troger's Base Derivatives Using beta-Cyclodextrin as Chiral Selector

Popis výsledku v původním jazyce

Racemic mixtures of six Troger's base derivatives were separated by chiral nonaqueous capillary electrophoresis. The separation protocol was optimized first for suitable solvents. Then the applicability of various salts dissolved in organic solvents andtheir mixtures was evaluated. As chiral selectors -cyclodextrin and heptakis(2,6-di-O-methyl)--cyclodextrin at various concentrations were used. The best enantioselectivity for the studied analytes was obtained utilizing formamide as organic nonaqueous solvent containing a mixture of sodium citrate and tris(hydroxymethyl)aminomethane acetate as electrolytes, and -cyclodextrin as chiral additive. The experimental results demonstrated the feasibility of nonaqueous capillary electrophoresis for enantioseparation of Troger's base derivatives. This technique represents a suitable alternative to more commonly used capillary electrophoresis in aqueous environment. Chirality 25:810-813, 2013. (c) 2013 Wiley Periodicals, Inc.

Název v anglickém jazyce

Nonaqueous Capillary Electrophoretic Enantioseparation of Water Insoluble Troger's Base Derivatives Using beta-Cyclodextrin as Chiral Selector

Popis výsledku anglicky

Racemic mixtures of six Troger's base derivatives were separated by chiral nonaqueous capillary electrophoresis. The separation protocol was optimized first for suitable solvents. Then the applicability of various salts dissolved in organic solvents andtheir mixtures was evaluated. As chiral selectors -cyclodextrin and heptakis(2,6-di-O-methyl)--cyclodextrin at various concentrations were used. The best enantioselectivity for the studied analytes was obtained utilizing formamide as organic nonaqueous solvent containing a mixture of sodium citrate and tris(hydroxymethyl)aminomethane acetate as electrolytes, and -cyclodextrin as chiral additive. The experimental results demonstrated the feasibility of nonaqueous capillary electrophoresis for enantioseparation of Troger's base derivatives. This technique represents a suitable alternative to more commonly used capillary electrophoresis in aqueous environment. Chirality 25:810-813, 2013. (c) 2013 Wiley Periodicals, Inc.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/GAP206%2F12%2F0453" target="_blank" >GAP206/12/0453: Afinitní kapilární elektromigrační metody pro selektivní nanoanalýzu biomolekul a studium jejich interakcí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chirality

ISSN

0899-0042

e-ISSN

—

Svazek periodika

25

Číslo periodika v rámci svazku

11

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

4

Strana od-do

810-813

Kód UT WoS článku

000326291700020

EID výsledku v databázi Scopus

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