Enantioseparation of Tröger?s base derivatives by capillary electrophoresis using cyclodextrins as chiral selectors

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895065" target="_blank" >RIV/60461373:22340/13:43895065 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1002/chir.22148" target="_blank" >http://dx.doi.org/10.1002/chir.22148</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1002/chir.22148" target="_blank" >10.1002/chir.22148</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Enantioseparation of Tröger?s base derivatives by capillary electrophoresis using cyclodextrins as chiral selectors

Popis výsledku v původním jazyce

The enantioseparation of seven Troger's base derivatives (TBs) was carried out by capillary electrophoresis using alpha-, beta-, and gamma-cyclodextrins as chiral selectors and phosphate at 20 mmol/l concentration, pH 2.5, as background electrolyte. Themethod was optimized with respect to the concentration of chosen chiral selectors (0-50 mmol/l) and the amount of organic solvent (acetonitrile, 0-25 % (v/v)) in the electrolyte. The results indicate that all the studied variables, i.e., type of chiral selector, its concentration, and the amount of the added organic solvent, have a significant impact on the enantioseparation of the studied TBs. The best results for the majority of the separated TBs were obtained utilizing beta-cyclodextrin at 5 mmol/l concentration and with various amounts of acetonitrile added ranging from 5 to 15% (v/v) in the background electrolyte. For the two smallest studied TBs, gamma-cyclodextrin with 10% (v/v) acetonitrile also provided good resolution.

Název v anglickém jazyce

Enantioseparation of Tröger?s base derivatives by capillary electrophoresis using cyclodextrins as chiral selectors

Popis výsledku anglicky

The enantioseparation of seven Troger's base derivatives (TBs) was carried out by capillary electrophoresis using alpha-, beta-, and gamma-cyclodextrins as chiral selectors and phosphate at 20 mmol/l concentration, pH 2.5, as background electrolyte. Themethod was optimized with respect to the concentration of chosen chiral selectors (0-50 mmol/l) and the amount of organic solvent (acetonitrile, 0-25 % (v/v)) in the electrolyte. The results indicate that all the studied variables, i.e., type of chiral selector, its concentration, and the amount of the added organic solvent, have a significant impact on the enantioseparation of the studied TBs. The best results for the majority of the separated TBs were obtained utilizing beta-cyclodextrin at 5 mmol/l concentration and with various amounts of acetonitrile added ranging from 5 to 15% (v/v) in the background electrolyte. For the two smallest studied TBs, gamma-cyclodextrin with 10% (v/v) acetonitrile also provided good resolution.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

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Projekt

<a href="/cs/project/GAP206%2F12%2F0453" target="_blank" >GAP206/12/0453: Afinitní kapilární elektromigrační metody pro selektivní nanoanalýzu biomolekul a studium jejich interakcí</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chirality

ISSN

0899-0042

e-ISSN

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Svazek periodika

25

Číslo periodika v rámci svazku

7

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

5

Strana od-do

379-383

Kód UT WoS článku

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EID výsledku v databázi Scopus

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