Use of 6-O-mono-substituted derivatives of β-cyclodextrin-bearing substituent with two permanent positive charges in capillary electrophoresis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F00216208%3A11310%2F16%3A10325009" target="_blank" >RIV/00216208:11310/16:10325009 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1515/chempap-2016-0053" target="_blank" >http://dx.doi.org/10.1515/chempap-2016-0053</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1515/chempap-2016-0053" target="_blank" >10.1515/chempap-2016-0053</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Use of 6-O-mono-substituted derivatives of β-cyclodextrin-bearing substituent with two permanent positive charges in capillary electrophoresis

Popis výsledku v původním jazyce

This study details the use of two permanently positively charged mono-substituted beta-cyclodextrin derivatives, 6(I)-deoxy-6(I)-(N,N,N',N',N'-pentamethyl-ethylene-1,2-diammonio)-cyclomaltoheptose dichloride (PEMEDA-beta-CD) and the newly synthesised 6(I)-deoxy-6(I)-(N,N,N',N',N'-pentamethylpropylene-1,3-diammonio)-cyclomaltoheptose (PEMPDA-beta-CD) as chiral selectors in capillary electrophoresis. Cyclodextrin (CD) derivatives were tested as additives in various buffers at various pH values with the optional addition of an organic modifier. Fourteen anionogenic analytes were tested, including native amino acids, N-blocked amino acids and profens, which were detected using a UV-VIS detector at optimal wavelengths of 214 nm, 254 nm or 280 nm. A borate buffer (15 mmol L-1) at pH 9.5 without the addition of an organic modifier was chosen as a suitable background electrolyte. In addition, the effect of the concentration of the chiral selector on the separation and enantioseparation of selected analytes was monitored. The additions of cyclodextrin derivatives varied within the concentration range of 0.0-5.0 mmol L-1. Both chiral selectors were suitable for the enantioseparation of N-Boc-D, L-tryptophan, which was already separated on the baseline at 0.5 mmol L-1 concentration of the chiral selector. (c) 2016 Institute of Chemistry, Slovak Academy of Sciences

Název v anglickém jazyce

Use of 6-O-mono-substituted derivatives of β-cyclodextrin-bearing substituent with two permanent positive charges in capillary electrophoresis

Popis výsledku anglicky

This study details the use of two permanently positively charged mono-substituted beta-cyclodextrin derivatives, 6(I)-deoxy-6(I)-(N,N,N',N',N'-pentamethyl-ethylene-1,2-diammonio)-cyclomaltoheptose dichloride (PEMEDA-beta-CD) and the newly synthesised 6(I)-deoxy-6(I)-(N,N,N',N',N'-pentamethylpropylene-1,3-diammonio)-cyclomaltoheptose (PEMPDA-beta-CD) as chiral selectors in capillary electrophoresis. Cyclodextrin (CD) derivatives were tested as additives in various buffers at various pH values with the optional addition of an organic modifier. Fourteen anionogenic analytes were tested, including native amino acids, N-blocked amino acids and profens, which were detected using a UV-VIS detector at optimal wavelengths of 214 nm, 254 nm or 280 nm. A borate buffer (15 mmol L-1) at pH 9.5 without the addition of an organic modifier was chosen as a suitable background electrolyte. In addition, the effect of the concentration of the chiral selector on the separation and enantioseparation of selected analytes was monitored. The additions of cyclodextrin derivatives varied within the concentration range of 0.0-5.0 mmol L-1. Both chiral selectors were suitable for the enantioseparation of N-Boc-D, L-tryptophan, which was already separated on the baseline at 0.5 mmol L-1 concentration of the chiral selector. (c) 2016 Institute of Chemistry, Slovak Academy of Sciences

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CB - Analytická chemie, separace

OECD FORD obor

—

Projekt

<a href="/cs/project/GA13-01440S" target="_blank" >GA13-01440S: Chirální supramolekulární polymery založené na derivatizovaných cyklodextrinech jako nové prostředí pro kapilární separační techniky</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Papers

ISSN

0366-6352

e-ISSN

—

Svazek periodika

70

Číslo periodika v rámci svazku

9

Stát vydavatele periodika

SK - Slovenská republika

Počet stran výsledku

11

Strana od-do

1144-1154

Kód UT WoS článku

000378599000002

EID výsledku v databázi Scopus

2-s2.0-84974555859