Separation of cetirizine enantiomers by capillary electrophoresis with a dual selector system based on borate-glucose complexes and sulfated-beta-cyclodextrin

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61989592%3A15310%2F19%3A73597890" target="_blank" >RIV/61989592:15310/19:73597890 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0039914019300682" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0039914019300682</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.talanta.2019.01.097" target="_blank" >10.1016/j.talanta.2019.01.097</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Separation of cetirizine enantiomers by capillary electrophoresis with a dual selector system based on borate-glucose complexes and sulfated-beta-cyclodextrin

Popis výsledku v původním jazyce

The aim of this study was to focus on the reduction of chiral selector concentration, sulfated-beta-cyclodextrin, in an attempt decrease the running costs associated with separating cetirizine enantiomers by capillary electrophoresis. The decrease in the concentration of chiral selector was achieved by adding D-glucose to the background electrolyte, which consisted of sodium borate. Optimal separation of cetirizine enantiomers was obtained in the electrolyte containing 500 mmol L-1 borate pH 9.5 with 1.0 mg mL(-1) sulfated-beta-cyclodextrin, and 1000 mmol L-1 D-glucose. This means a 15-fold reduction in the concentration of sulfated-beta-cyclodextrin. The mechanism of the separation in this electrolyte was investigated using direct injection mass spectrometry. The electrolyte of borate, D-glucose, and sulfated-beta-cyclodextrin forms a dual selector system, in which one selector is represented by the sulfated-beta-cyclodextrin and the second selector is represented by the D-glucose-borate complexes.

Název v anglickém jazyce

Separation of cetirizine enantiomers by capillary electrophoresis with a dual selector system based on borate-glucose complexes and sulfated-beta-cyclodextrin

Popis výsledku anglicky

The aim of this study was to focus on the reduction of chiral selector concentration, sulfated-beta-cyclodextrin, in an attempt decrease the running costs associated with separating cetirizine enantiomers by capillary electrophoresis. The decrease in the concentration of chiral selector was achieved by adding D-glucose to the background electrolyte, which consisted of sodium borate. Optimal separation of cetirizine enantiomers was obtained in the electrolyte containing 500 mmol L-1 borate pH 9.5 with 1.0 mg mL(-1) sulfated-beta-cyclodextrin, and 1000 mmol L-1 D-glucose. This means a 15-fold reduction in the concentration of sulfated-beta-cyclodextrin. The mechanism of the separation in this electrolyte was investigated using direct injection mass spectrometry. The electrolyte of borate, D-glucose, and sulfated-beta-cyclodextrin forms a dual selector system, in which one selector is represented by the sulfated-beta-cyclodextrin and the second selector is represented by the D-glucose-borate complexes.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

<a href="/cs/project/LO1305" target="_blank" >LO1305: Rozvoj centra pokročilých technologií a materiálů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)<br>S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

TALANTA

ISSN

0039-9140

e-ISSN

—

Svazek periodika

198

Číslo periodika v rámci svazku

JUN

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

5

Strana od-do

154-158

Kód UT WoS článku

000462803400021

EID výsledku v databázi Scopus

2-s2.0-85061106411