On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F13%3A43895784" target="_blank" >RIV/60461373:22340/13:43895784 - isvavai.cz</a>

Výsledek na webu

<a href="http://scitation.aip.org/content/aip/journal/jcp/138/6/10.1063/1.4790126" target="_blank" >http://scitation.aip.org/content/aip/journal/jcp/138/6/10.1063/1.4790126</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1063/1.4790126" target="_blank" >10.1063/1.4790126</a>

Jazyk výsledku

angličtina

Název v původním jazyce

On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling

Popis výsledku v původním jazyce

Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. Successive phosphorylation cascades mediated by MAPKs serve as sensitive switches initiating various cellular processes. Apart from this basic feature, the underlying reaction network is capable of displaying other nonlinear phenomena including bistable steady states and hysteresis as well as periodic oscillations. We show that from the mechanistic point of view, bistability is a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in a Stage 2 subsystem of the Huang-Ferrell model. Within this subsystem we uncover the core subnetwork obtained by systematic reduction relying on the methods of stoichiometric network analysis. For the core model we show that there is either one stable steady state or three steady states of which two are stable and point out the role of interplay betwe

Název v anglickém jazyce

On the origin of bistability in the Stage 2 of the Huang-Ferrell model of the MAPK signaling

Popis výsledku anglicky

Mitogen-activated protein kinases (MAPKs) are important signal transducing enzymes, unique to eukaryotes, that are involved in many pathways of cellular regulation. Successive phosphorylation cascades mediated by MAPKs serve as sensitive switches initiating various cellular processes. Apart from this basic feature, the underlying reaction network is capable of displaying other nonlinear phenomena including bistable steady states and hysteresis as well as periodic oscillations. We show that from the mechanistic point of view, bistability is a consequence of interaction between single and double phosphorylation/dephosphorylation pathways in a Stage 2 subsystem of the Huang-Ferrell model. Within this subsystem we uncover the core subnetwork obtained by systematic reduction relying on the methods of stoichiometric network analysis. For the core model we show that there is either one stable steady state or three steady states of which two are stable and point out the role of interplay betwe

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/ME10036" target="_blank" >ME10036: Vliv konvektivního toku na šíření chemického signálu v živých tkáních</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Chemical Physics

ISSN

0021-9606

e-ISSN

—

Svazek periodika

138

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

"065102-1"-"065102-10"

Kód UT WoS článku

000315054400043

EID výsledku v databázi Scopus

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