The construction, prediction and measurement of co-crystal ternary phase diagrams as a tool for solvent selection

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F14%3A43897544" target="_blank" >RIV/60461373:22340/14:43897544 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ejps.2014.06.017" target="_blank" >http://dx.doi.org/10.1016/j.ejps.2014.06.017</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ejps.2014.06.017" target="_blank" >10.1016/j.ejps.2014.06.017</a>

Jazyk výsledku

angličtina

Název v původním jazyce

The construction, prediction and measurement of co-crystal ternary phase diagrams as a tool for solvent selection

Popis výsledku v původním jazyce

Many active pharmaceutical ingredients (APIs) are poorly soluble and therefore poorly bioavailable. In recent years, the advances in crystal engineering have motivated the research in the design of pharmaceutical co-crystals. This study examines the combination of solvent selection and co-crystal ternary phase diagram prediction on the basis of solubility measurements into a single methodology that can be integrated into the pharmaceutical process development workflow. Ternary diagrams constructed fromagomelatine citric acid co-crystal solubility data were compared with those obtained by modern calorimetric method called discontinuous isoperibolic thermal analysis (DITA). A suitable solvent for the co-crystallization process has been chosen on the basis of agomelatine citric acid co-crystal solubility, which is connected to the yield of the crystallization process. Furthermore, the quality of final crystals from crystallization experiments was evaluated.

Název v anglickém jazyce

The construction, prediction and measurement of co-crystal ternary phase diagrams as a tool for solvent selection

Popis výsledku anglicky

Many active pharmaceutical ingredients (APIs) are poorly soluble and therefore poorly bioavailable. In recent years, the advances in crystal engineering have motivated the research in the design of pharmaceutical co-crystals. This study examines the combination of solvent selection and co-crystal ternary phase diagram prediction on the basis of solubility measurements into a single methodology that can be integrated into the pharmaceutical process development workflow. Ternary diagrams constructed fromagomelatine citric acid co-crystal solubility data were compared with those obtained by modern calorimetric method called discontinuous isoperibolic thermal analysis (DITA). A suitable solvent for the co-crystallization process has been chosen on the basis of agomelatine citric acid co-crystal solubility, which is connected to the yield of the crystallization process. Furthermore, the quality of final crystals from crystallization experiments was evaluated.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Journal of Pharmaceutical Sciences

ISSN

0928-0987

e-ISSN

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Svazek periodika

63

Číslo periodika v rámci svazku

OCT15 2014

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

"124?131"

Kód UT WoS článku

000343388300016

EID výsledku v databázi Scopus

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