Design of co-crystallization processes with regard to particle size distribution
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43900005" target="_blank" >RIV/60461373:22340/15:43900005 - isvavai.cz</a>
Výsledek na webu
<a href="http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=7&SID=T1fZeoH1ToTyfCMlrRY&page=1&doc=1" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=WOS&search_mode=GeneralSearch&qid=7&SID=T1fZeoH1ToTyfCMlrRY&page=1&doc=1</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.ces.2015.01.045" target="_blank" >10.1016/j.ces.2015.01.045</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Design of co-crystallization processes with regard to particle size distribution
Popis výsledku v původním jazyce
Many active pharmaceutical ingredients (APIs) are poorly soluble and therefore poorly bioavailable. Advances in crystal engineering have motivated research into the design of pharmaceutical co-crystals. This study examines the formation of agomelatine-citric acid co-crystal in a batch cooling crystallization. Three linear cooling profiles (10 degrees C, 20 degrees C and 30 degrees C/h) were applied for both unseeded and seeded crystallization and the effect of the seeding temperature on the final crystal size distribution was systematically investigated. A mathematical model of the crystallization process, consisting of the population and mass balance, was formulated and solved using the finite difference method. The growth and nucleation rate constants were evaluated iteratively by the comparison of measured and simulated crystal size distributions. The similarities and differences between classical single-component crystallization and co-crystallization were discussed.
Název v anglickém jazyce
Design of co-crystallization processes with regard to particle size distribution
Popis výsledku anglicky
Many active pharmaceutical ingredients (APIs) are poorly soluble and therefore poorly bioavailable. Advances in crystal engineering have motivated research into the design of pharmaceutical co-crystals. This study examines the formation of agomelatine-citric acid co-crystal in a batch cooling crystallization. Three linear cooling profiles (10 degrees C, 20 degrees C and 30 degrees C/h) were applied for both unseeded and seeded crystallization and the effect of the seeding temperature on the final crystal size distribution was systematically investigated. A mathematical model of the crystallization process, consisting of the population and mass balance, was formulated and solved using the finite difference method. The growth and nucleation rate constants were evaluated iteratively by the comparison of measured and simulated crystal size distributions. The similarities and differences between classical single-component crystallization and co-crystallization were discussed.
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CI - Průmyslová chemie a chemické inženýrství
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA15-05534S" target="_blank" >GA15-05534S: Studie vztahu mezi strukturou a vlastnostmi složitých granulárních systémů a dynamiky jejich lámání</a><br>
Návaznosti
S - Specificky vyzkum na vysokych skolach
Ostatní
Rok uplatnění
2015
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Chemical Engineering Science
ISSN
0009-2509
e-ISSN
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Svazek periodika
128
Číslo periodika v rámci svazku
MAY 25 2015
Stát vydavatele periodika
GB - Spojené království Velké Británie a Severního Irska
Počet stran výsledku
8
Strana od-do
36-43
Kód UT WoS článku
000351945600005
EID výsledku v databázi Scopus
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