Synthesis and characterization of composite hollow porous lipide/fe3o4/sio2 nanoparticles for controlled release of active substances

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Synthesis and characterization of composite hollow porous lipide/fe3o4/sio2 nanoparticles for controlled release of active substances

Popis výsledku v původním jazyce

The goal was to prepare composite lipide/Fe3O4/SiO2 nanoparticles from hollow porous silica shell nanoparticles (100-300 nm) prepared by soft template emulsion method, magnetic iron oxide nanoparticles (5-20 nm) prepared by co-precipitation method and lipide nanoparticles (20-40 nm) prepared by high pressure homogenization.. First composite Fe3O4/SiO2 nanoparticles were prepared by coating silica with monolayer of iron oxide. The composite particles was then loaded with active substance and coated withlayer of lipide nanoparticles to form oclusive lipide barrier which block diffusion in and out of the particles, thus preserving the active substance inside. The particles were cahracterised using transmission electron microscopy, dynamic light scattering and electrophoretic light scattering. The release mechanism is triggered by alternating radiofrequency field which heats up the magnetic iron oxide particles and melts the lipidic barrier which opens pores and the active substance diffu

Název v anglickém jazyce

Synthesis and characterization of composite hollow porous lipide/fe3o4/sio2 nanoparticles for controlled release of active substances

Popis výsledku anglicky

The goal was to prepare composite lipide/Fe3O4/SiO2 nanoparticles from hollow porous silica shell nanoparticles (100-300 nm) prepared by soft template emulsion method, magnetic iron oxide nanoparticles (5-20 nm) prepared by co-precipitation method and lipide nanoparticles (20-40 nm) prepared by high pressure homogenization.. First composite Fe3O4/SiO2 nanoparticles were prepared by coating silica with monolayer of iron oxide. The composite particles was then loaded with active substance and coated withlayer of lipide nanoparticles to form oclusive lipide barrier which block diffusion in and out of the particles, thus preserving the active substance inside. The particles were cahracterised using transmission electron microscopy, dynamic light scattering and electrophoretic light scattering. The release mechanism is triggered by alternating radiofrequency field which heats up the magnetic iron oxide particles and melts the lipidic barrier which opens pores and the active substance diffu

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 41st International Conference of Slovak Society of Chemical Engineering

ISBN

978-80-89475-13-1

ISSN

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e-ISSN

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Počet stran výsledku

10

Strana od-do

807-816

Název nakladatele

Slovak Society of Chemical Engineering

Místo vydání

Bratislava

Místo konání akce

Tatranské Matliare

Datum konání akce

26. 5. 2014

Typ akce podle státní příslušnosti

EUR - Evropská akce

Kód UT WoS článku

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