Silica-coated .gamma.-Fe2O3 nanoparticles: preparation and engulfment by mammalian macrophages

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F13%3A00394385" target="_blank" >RIV/61389013:_____/13:00394385 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985530:_____/13:00394385

Výsledek na webu

<a href="http://dx.doi.org/10.1166/jnd.2013.1020" target="_blank" >http://dx.doi.org/10.1166/jnd.2013.1020</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1166/jnd.2013.1020" target="_blank" >10.1166/jnd.2013.1020</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Silica-coated .gamma.-Fe2O3 nanoparticles: preparation and engulfment by mammalian macrophages

Popis výsledku v původním jazyce

Maghemite (?-Fe2O3) nanoparticles were prepared by coprecipitation of Fe(II) and Fe(III) salts followed by oxidation of Fe3O4 with sodium hypochlorite. The ?-Fe2O3 nanoparticles were then coated by a silica shell using tetramethyl orthosilicate producing?-Fe2O3@SiO2 particles. In order to introduce amino groups, the surface of the ?-Fe2O3@SiO2 particles was coated with a second silica shell using (3-aminopropyl)triethoxysilane, resulting in ?-Fe2O3@SiO2-NH2 nanoparticles. The particles were characterized by scanning and transmission electron microscopy (SEM and TEM), dynamic light scattering (DLS) and Fourier-transform infrared (FT-IR) spectroscopy in terms of determination of morphology, particle size, polydispersity and presence of functional groups. Atomic absorption spectroscopy (AAS) was used for determination of the iron content. Moreover, induced magnetization and temperature-dependent magnetic susceptibility were investigated. In the biological experiments, ?-Fe2O3@SiO2 and ?-

Název v anglickém jazyce

Silica-coated .gamma.-Fe2O3 nanoparticles: preparation and engulfment by mammalian macrophages

Popis výsledku anglicky

Maghemite (?-Fe2O3) nanoparticles were prepared by coprecipitation of Fe(II) and Fe(III) salts followed by oxidation of Fe3O4 with sodium hypochlorite. The ?-Fe2O3 nanoparticles were then coated by a silica shell using tetramethyl orthosilicate producing?-Fe2O3@SiO2 particles. In order to introduce amino groups, the surface of the ?-Fe2O3@SiO2 particles was coated with a second silica shell using (3-aminopropyl)triethoxysilane, resulting in ?-Fe2O3@SiO2-NH2 nanoparticles. The particles were characterized by scanning and transmission electron microscopy (SEM and TEM), dynamic light scattering (DLS) and Fourier-transform infrared (FT-IR) spectroscopy in terms of determination of morphology, particle size, polydispersity and presence of functional groups. Atomic absorption spectroscopy (AAS) was used for determination of the iron content. Moreover, induced magnetization and temperature-dependent magnetic susceptibility were investigated. In the biological experiments, ?-Fe2O3@SiO2 and ?-

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2013

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Nanopharmaceutics and Drug Delivery

ISSN

2167-9312

e-ISSN

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Svazek periodika

1

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

182-192

Kód UT WoS článku

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EID výsledku v databázi Scopus

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