Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe3O4&SiO2 core–shell nanoparticles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F17%3A00470671" target="_blank" >RIV/61389013:_____/17:00470671 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1039/C7RA00224F" target="_blank" >http://dx.doi.org/10.1039/C7RA00224F</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/C7RA00224F" target="_blank" >10.1039/C7RA00224F</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe3O4&SiO2 core–shell nanoparticles

Popis výsledku v původním jazyce

Monodisperse, superparamagnetic oleic acid-stabilized Fe3O4 nanoparticles of different sizes were prepared by thermal decomposition of Fe(III) oleate. The particles were subsequently coated by silica shells of different thicknesses (yielding Fe3O4&SiO2) using a water-in-oil (w/o) reverse microemulsion technique and/or were decorated with amino groups by reaction with (3-aminopropyl)triethoxysilane. The resulting Fe3O4&SiO2-NH2 nanoparticles were then modified with poly(ethylene glycol) (PEG) via reaction with its succinimidyl ester yielding Fe3O4&SiO2-PEG particles. The in vitro biocompatibility and biosafety of the Fe3O4&SiO2 and Fe3O4&SiO2-PEG particles were investigated in a murine neural stem cell model in terms of oxidative stress response and cell viability, proliferation, and uptake. Finally, the potential of both nanoparticle types for application in magnetic resonance imaging (MRI) visualization was evaluated.

Název v anglickém jazyce

Physico-chemical characteristics, biocompatibility, and MRI applicability of novel monodisperse PEG-modified magnetic Fe3O4&SiO2 core–shell nanoparticles

Popis výsledku anglicky

Monodisperse, superparamagnetic oleic acid-stabilized Fe3O4 nanoparticles of different sizes were prepared by thermal decomposition of Fe(III) oleate. The particles were subsequently coated by silica shells of different thicknesses (yielding Fe3O4&SiO2) using a water-in-oil (w/o) reverse microemulsion technique and/or were decorated with amino groups by reaction with (3-aminopropyl)triethoxysilane. The resulting Fe3O4&SiO2-NH2 nanoparticles were then modified with poly(ethylene glycol) (PEG) via reaction with its succinimidyl ester yielding Fe3O4&SiO2-PEG particles. The in vitro biocompatibility and biosafety of the Fe3O4&SiO2 and Fe3O4&SiO2-PEG particles were investigated in a murine neural stem cell model in terms of oxidative stress response and cell viability, proliferation, and uptake. Finally, the potential of both nanoparticle types for application in magnetic resonance imaging (MRI) visualization was evaluated.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

RSC Advances

ISSN

2046-2069

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

15

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

12

Strana od-do

8786-8797

Kód UT WoS článku

000393759900007

EID výsledku v databázi Scopus

2-s2.0-85011022704