Combined antitumor effect of surface-modified superparamagnetic maghemite nanoparticles and a vitamin E derivative on experimental Walker-256 mammary gland carcinosarcoma

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61389013%3A_____%2F19%3A00494217" target="_blank" >RIV/61389013:_____/19:00494217 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985530:_____/19:00494217

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0304885318312216?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0304885318312216?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jmmm.2018.10.006" target="_blank" >10.1016/j.jmmm.2018.10.006</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Combined antitumor effect of surface-modified superparamagnetic maghemite nanoparticles and a vitamin E derivative on experimental Walker-256 mammary gland carcinosarcoma

Popis výsledku v původním jazyce

In a search for efficient anti-tumor agent, silica-coated superparamagnetic nanoparticles were designed and used in combination with vitamin E derivative as a potential new tool for anticancer treatment. The particles were characterized by numerous techniques, such as transmission electron microscopy and dynamic light scattering to determine the particle morphology and size both in dry state and water, atomic absorption spectroscopy to analyze the iron content, Fourier-transform infrared spectroscopy to confirm the presence of the functional groups, and vibrating sample magnetometry to determine the magnetic properties and content of maghemite. The next aim was to assess effect of the nanoparticles on suppression of experimental mammary gland carcinosarcoma W-256. Strong antitumor effect was achieved only with combined application of γ-Fe2O3@SiO2 and acetate derivative of α-tocopherol (Toc-6-Ac) resulting in 58% of tumor volume reduction. The results were compared with those obtained with poly(N,N-dimethylacrylamide)-coated iron oxide particles described earlier.

Název v anglickém jazyce

Combined antitumor effect of surface-modified superparamagnetic maghemite nanoparticles and a vitamin E derivative on experimental Walker-256 mammary gland carcinosarcoma

Popis výsledku anglicky

In a search for efficient anti-tumor agent, silica-coated superparamagnetic nanoparticles were designed and used in combination with vitamin E derivative as a potential new tool for anticancer treatment. The particles were characterized by numerous techniques, such as transmission electron microscopy and dynamic light scattering to determine the particle morphology and size both in dry state and water, atomic absorption spectroscopy to analyze the iron content, Fourier-transform infrared spectroscopy to confirm the presence of the functional groups, and vibrating sample magnetometry to determine the magnetic properties and content of maghemite. The next aim was to assess effect of the nanoparticles on suppression of experimental mammary gland carcinosarcoma W-256. Strong antitumor effect was achieved only with combined application of γ-Fe2O3@SiO2 and acetate derivative of α-tocopherol (Toc-6-Ac) resulting in 58% of tumor volume reduction. The results were compared with those obtained with poly(N,N-dimethylacrylamide)-coated iron oxide particles described earlier.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/GA17-04918S" target="_blank" >GA17-04918S: Léčba glioblastomu pomocí superparamagnetických nanočástic na bázi oxidů železa s povrchově konjugovaným léčivem</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Magnetism and Magnetic Materials

ISSN

0304-8853

e-ISSN

—

Svazek periodika

471

Číslo periodika v rámci svazku

1 February

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

381-387

Kód UT WoS článku

000450089600054

EID výsledku v databázi Scopus

2-s2.0-85054315481