Remote control of enzymatic reaction in compartmentalized microparticles: A system for the delivery of unstable actives

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43900018" target="_blank" >RIV/60461373:22340/15:43900018 - isvavai.cz</a>

Výsledek na webu

<a href="http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=19&SID=U1pZHBSPBb1pKRGmC6q&page=1&doc=1" target="_blank" >http://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=19&SID=U1pZHBSPBb1pKRGmC6q&page=1&doc=1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ces.2014.06.020" target="_blank" >10.1016/j.ces.2014.06.020</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Remote control of enzymatic reaction in compartmentalized microparticles: A system for the delivery of unstable actives

Popis výsledku v původním jazyce

Control of biochemical reactions in living cells is based on the principle of compartmentalization, whereby the access of substrates to the active sites of enzymes is regulated by the structure of organelles with semi permeable membranes. The present work describes the fabrication of synthetic microparticies with a similar functionality and the possibility to control substrate access to an enzyme remotely by the application of radioirequency (RF) signals. Composite alginate hydrogel microparticles thatcontain iron oxide nanoparticles as local RF susceptors, liposomes that can undergo a reversible phase transition to control the release rate of encapsulated substrate, and an immobilized enzyme (laccase) that facilitates a reaction, were fabricated. Factors affecting the stability and the release kinetics have been investigated and the principle of remotely controllable on demand enzymatic reaction in the particles has been demonstrated. This principle makes it possible to deliver unsta

Název v anglickém jazyce

Remote control of enzymatic reaction in compartmentalized microparticles: A system for the delivery of unstable actives

Popis výsledku anglicky

Control of biochemical reactions in living cells is based on the principle of compartmentalization, whereby the access of substrates to the active sites of enzymes is regulated by the structure of organelles with semi permeable membranes. The present work describes the fabrication of synthetic microparticies with a similar functionality and the possibility to control substrate access to an enzyme remotely by the application of radioirequency (RF) signals. Composite alginate hydrogel microparticles thatcontain iron oxide nanoparticles as local RF susceptors, liposomes that can undergo a reversible phase transition to control the release rate of encapsulated substrate, and an immobilized enzyme (laccase) that facilitates a reaction, were fabricated. Factors affecting the stability and the release kinetics have been investigated and the principle of remotely controllable on demand enzymatic reaction in the particles has been demonstrated. This principle makes it possible to deliver unsta

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

—

Projekt

<a href="/cs/project/GA13-09914S" target="_blank" >GA13-09914S: Studium difuzních procesů v porézních látkách s proměnnou propustností</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Chemical Engineering Science

ISSN

0009-2509

e-ISSN

—

Svazek periodika

125

Číslo periodika v rámci svazku

MAR 24 2015

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

9

Strana od-do

191-199

Kód UT WoS článku

000349447500018

EID výsledku v databázi Scopus

—