EFFECT OF HYDROPHOBIC INCLUSIONS ON POLYMER SWELLING KINETICS STUDIED BY MAGNETIC RESONANCE IMAGING

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F15%3A43900357" target="_blank" >RIV/60461373:22340/15:43900357 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EFFECT OF HYDROPHOBIC INCLUSIONS ON POLYMER SWELLING KINETICS STUDIED BY MAGNETIC RESONANCE IMAGING

Popis výsledku v původním jazyce

Controlled delivery systems are widely used formulations in the pharmaceutical industry. Binding the active pharmaceutical ingredient (API) into the drug delivery system can solve some disadvantages of regular oral dosage forms. The simplest controlled delivery systems are polymeric matrices mixed with the API and excipients, further directly compressed into the tablet. Hydrophilic polymeric matrices create a gel layer after contact with a dissolution medium. This gel layer represents the regulation mechanism of the API liberation (by influencing the water penetration into the solid core of the tablet, its diffusion through the gel layer, the drug particle dissolution and the diffusion through the gel layer or the polymer chain disentanglement). Despite the remarkable accomplishments in this field of study, there are still a lot of unknowns in the design of swellable drug delivery systems. It is complicated to produce the final formulation with desired dissolution profile of the API. I

Název v anglickém jazyce

EFFECT OF HYDROPHOBIC INCLUSIONS ON POLYMER SWELLING KINETICS STUDIED BY MAGNETIC RESONANCE IMAGING

Popis výsledku anglicky

Controlled delivery systems are widely used formulations in the pharmaceutical industry. Binding the active pharmaceutical ingredient (API) into the drug delivery system can solve some disadvantages of regular oral dosage forms. The simplest controlled delivery systems are polymeric matrices mixed with the API and excipients, further directly compressed into the tablet. Hydrophilic polymeric matrices create a gel layer after contact with a dissolution medium. This gel layer represents the regulation mechanism of the API liberation (by influencing the water penetration into the solid core of the tablet, its diffusion through the gel layer, the drug particle dissolution and the diffusion through the gel layer or the polymer chain disentanglement). Despite the remarkable accomplishments in this field of study, there are still a lot of unknowns in the design of swellable drug delivery systems. It is complicated to produce the final formulation with desired dissolution profile of the API. I

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/GA13-09914S" target="_blank" >GA13-09914S: Studium difuzních procesů v porézních látkách s proměnnou propustností</a><br>

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 3rd International Conference on Chemical Technology

ISBN

978-80-86238-79-1

ISSN

2336-811X

e-ISSN

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Počet stran výsledku

5

Strana od-do

489-493

Název nakladatele

Česká společnost průmyslové chemie (ČSPCH)

Místo vydání

Praha

Místo konání akce

Mikulov

Datum konání akce

13. 4. 2015

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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