Characterization of Solid Dispersions Prepared by Melting Method

Kód výsledku v IS VaVaI

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Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Characterization of Solid Dispersions Prepared by Melting Method

Popis výsledku v původním jazyce

Nowadays, the pharmaceutical industry faces a challenge to formulate a large number of APIs that are almost insoluble in aqueous media. The preparation of solid dispersions (SD) is one of the promising methods for improving drug solubility and bioavailability. SDs are mostly binary API-polymer systems, where API is molecularly dispersed in a polymeric matrix. Thus, the aim of this work was to prepare SDs by melting method and compare them with corresponding physical mixtures (PM). Paracetamol was used as a model drug, which was mixed with three different hydrophilic polymer matrices (Kollidon® VA 64, Kollidon® 12 PF and Soluplus®) in various ratios. It was shown that the polymer type has an influence on the surface energy values and the dissolution rates of drugs. Moreover, it was found that the higher concentration of paracetamol in solid dispersions, and also the lower hardness of tablets cause faster dissolution.

Název v anglickém jazyce

Characterization of Solid Dispersions Prepared by Melting Method

Popis výsledku anglicky

Nowadays, the pharmaceutical industry faces a challenge to formulate a large number of APIs that are almost insoluble in aqueous media. The preparation of solid dispersions (SD) is one of the promising methods for improving drug solubility and bioavailability. SDs are mostly binary API-polymer systems, where API is molecularly dispersed in a polymeric matrix. Thus, the aim of this work was to prepare SDs by melting method and compare them with corresponding physical mixtures (PM). Paracetamol was used as a model drug, which was mixed with three different hydrophilic polymer matrices (Kollidon® VA 64, Kollidon® 12 PF and Soluplus®) in various ratios. It was shown that the polymer type has an influence on the surface energy values and the dissolution rates of drugs. Moreover, it was found that the higher concentration of paracetamol in solid dispersions, and also the lower hardness of tablets cause faster dissolution.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 7th International Conference on Chemical Technology

ISBN

978-80-88307-00-6

ISSN

2336-811X

e-ISSN

2336-8128

Počet stran výsledku

6

Strana od-do

281-286

Název nakladatele

Czech Society of Industrial Chemistry

Místo vydání

Prague

Místo konání akce

Mikulov

Datum konání akce

15. 4. 2019

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

000515696600051