Preparation of solid dispersions with respect to the dissolution rate of active substance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F20%3A43920842" target="_blank" >RIV/60461373:22310/20:43920842 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1773224719315084" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224719315084</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jddst.2020.101518" target="_blank" >10.1016/j.jddst.2020.101518</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of solid dispersions with respect to the dissolution rate of active substance

Popis výsledku v původním jazyce

Solid dispersions (SDs) are one of the successfully applied methods to improve the solubility and dissolution rates of poorly water-soluble drugs. SDs are commonly API-polymer systems, where API is molecularly dispersed in a polymeric matrix. The objective of this study was to prepare SDs by different techniques and with different polymeric matrices and compare them with the physical mixtures in terms of dissolution properties. Tadalafil was used as a model poorly water-soluble drug, which was combined with hydrophilic polymers Kollidon® 12 PF, Kollidon® VA 64 and Soluplus®. Our results show that as the molecular weight of polymer increased, hydrophilic polymer swelled more during the dissolution and on the contrary, the drug release decreased. In this case, it means, that the presence of both Kollidons has a positive effect on the acceleration of tadalafil release, on the other hand, the presence of Soluplus® retarded its release. The apparent intrinsic dissolution measurements were used to separate the dissolution effects from those related to particle size. These results indicate the possibility of different applications of SDs in pharmaceutical formulations, based on careful selection of the polymer co-former and it might be useful for the drug tailoring.

Název v anglickém jazyce

Preparation of solid dispersions with respect to the dissolution rate of active substance

Popis výsledku anglicky

Solid dispersions (SDs) are one of the successfully applied methods to improve the solubility and dissolution rates of poorly water-soluble drugs. SDs are commonly API-polymer systems, where API is molecularly dispersed in a polymeric matrix. The objective of this study was to prepare SDs by different techniques and with different polymeric matrices and compare them with the physical mixtures in terms of dissolution properties. Tadalafil was used as a model poorly water-soluble drug, which was combined with hydrophilic polymers Kollidon® 12 PF, Kollidon® VA 64 and Soluplus®. Our results show that as the molecular weight of polymer increased, hydrophilic polymer swelled more during the dissolution and on the contrary, the drug release decreased. In this case, it means, that the presence of both Kollidons has a positive effect on the acceleration of tadalafil release, on the other hand, the presence of Soluplus® retarded its release. The apparent intrinsic dissolution measurements were used to separate the dissolution effects from those related to particle size. These results indicate the possibility of different applications of SDs in pharmaceutical formulations, based on careful selection of the polymer co-former and it might be useful for the drug tailoring.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Drug Delivery Science and Technology

ISSN

1773-2247

e-ISSN

—

Svazek periodika

56

Číslo periodika v rámci svazku

A

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

9

Strana od-do

"article number 101518"

Kód UT WoS článku

000542128500009

EID výsledku v databázi Scopus

—