EFFECT OF HYDROPHILIC POLYMERS ON DISSOLUTION PROFILES OF BINARY MIXTURES

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F17%3A43915241" target="_blank" >RIV/60461373:22310/17:43915241 - isvavai.cz</a>

Výsledek na webu

<a href="http://www.icct.cz/AngiologyKlon-ICCT/media/system/ICCT2017-full_papers.pdf" target="_blank" >http://www.icct.cz/AngiologyKlon-ICCT/media/system/ICCT2017-full_papers.pdf</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

EFFECT OF HYDROPHILIC POLYMERS ON DISSOLUTION PROFILES OF BINARY MIXTURES

Popis výsledku v původním jazyce

Solubility and dissolution rate are limiting step in absorption of an active pharmaceutical ingredient (API), especially for a poorly water-soluble drug substance. This study is aimed at determining the effect of hydrophilic polymers (Kollidon? 12 PF, Kollidon? VA 64 or Soluplus?) on dissolution profiles of acetaminophen binary mixtures: physical mixtures of API and polymer and corresponding solid dispersions which were prepared by melt method. An erosion-diffusion mechanism of acetaminophen release was also evaluated. The Wood apparatus was used to determine the intrinsic dissolution rate of acetaminophen and its dissolution profiles of release were measured using a flow-through cell apparatus in an open-loop configuration (USP4). It was found that all of hydrophilic polymers formed gel layer. Kollidon? VA 64 and Soluplus? retarded the acetaminophen release and thus, the diffusion mechanism dominated. On the other hand, Kollidon? 12 PF accelerated the acetaminophen release and in this case, the erosion mechanism dominated.

Název v anglickém jazyce

EFFECT OF HYDROPHILIC POLYMERS ON DISSOLUTION PROFILES OF BINARY MIXTURES

Popis výsledku anglicky

Solubility and dissolution rate are limiting step in absorption of an active pharmaceutical ingredient (API), especially for a poorly water-soluble drug substance. This study is aimed at determining the effect of hydrophilic polymers (Kollidon? 12 PF, Kollidon? VA 64 or Soluplus?) on dissolution profiles of acetaminophen binary mixtures: physical mixtures of API and polymer and corresponding solid dispersions which were prepared by melt method. An erosion-diffusion mechanism of acetaminophen release was also evaluated. The Wood apparatus was used to determine the intrinsic dissolution rate of acetaminophen and its dissolution profiles of release were measured using a flow-through cell apparatus in an open-loop configuration (USP4). It was found that all of hydrophilic polymers formed gel layer. Kollidon? VA 64 and Soluplus? retarded the acetaminophen release and thus, the diffusion mechanism dominated. On the other hand, Kollidon? 12 PF accelerated the acetaminophen release and in this case, the erosion mechanism dominated.

Druh

D - Stať ve sborníku

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

Proceedings of the 5th International Conference on Chemical Technology

ISBN

978-80-86238-65-4

ISSN

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e-ISSN

neuvedeno

Počet stran výsledku

5

Strana od-do

445-449

Název nakladatele

Česká společnost průmyslové chemie (ČSPCH)

Místo vydání

Praha

Místo konání akce

Mikulov

Datum konání akce

10. 4. 2017

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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