Preparation of solid dispersion with respect to the dissolution rate of active substance

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22310%2F19%3A43919584" target="_blank" >RIV/60461373:22310/19:43919584 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sheffield.ac.uk/agglom/2019/index#" target="_blank" >https://www.sheffield.ac.uk/agglom/2019/index#</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Preparation of solid dispersion with respect to the dissolution rate of active substance

Popis výsledku v původním jazyce

Solid dispersions (SDs) are one of widely and successfully applied methods to improve the solubility, dissolution rates and the bioavailability of poorly water-soluble drugs. SDs are commonly binary API-polymer systems, where API is molecularly dispersed in a polymeric matrix. Thus, the objective of this study was to prepare SDs by solvent evaporation and spray drying method and compare them with the physical mixtures (PMs) in terms of dissolution properties. Tadalafil was used as a model poorly water-soluble drug, which was mixed with three different hydrophilic polymer matrices, Kollidon® VA 64, Kollidon® 12 PF and Soluplus®. It was confirmed that hydrophilic polymers have a significant influence on the drug release from binary mixtures (SDs or PMs). The type of hydrophilic polymer can control if the drug release is either immediate or prolonged. Our results show that as the molecular weight of polymer increased, hydrophilic polymer more swollen and on the contrary, the drug release decreased. In this case of SDs, it means, that the presence of both Kollidons has a positive effect on the acceleration of tadalafil release, on the other hand, the presence of Soluplus® retarded its release. These results indicate possibility of different applications of SDs in pharmaceutical formulation, based on careful selection of the polymer co-former.

Název v anglickém jazyce

Preparation of solid dispersion with respect to the dissolution rate of active substance

Popis výsledku anglicky

Solid dispersions (SDs) are one of widely and successfully applied methods to improve the solubility, dissolution rates and the bioavailability of poorly water-soluble drugs. SDs are commonly binary API-polymer systems, where API is molecularly dispersed in a polymeric matrix. Thus, the objective of this study was to prepare SDs by solvent evaporation and spray drying method and compare them with the physical mixtures (PMs) in terms of dissolution properties. Tadalafil was used as a model poorly water-soluble drug, which was mixed with three different hydrophilic polymer matrices, Kollidon® VA 64, Kollidon® 12 PF and Soluplus®. It was confirmed that hydrophilic polymers have a significant influence on the drug release from binary mixtures (SDs or PMs). The type of hydrophilic polymer can control if the drug release is either immediate or prolonged. Our results show that as the molecular weight of polymer increased, hydrophilic polymer more swollen and on the contrary, the drug release decreased. In this case of SDs, it means, that the presence of both Kollidons has a positive effect on the acceleration of tadalafil release, on the other hand, the presence of Soluplus® retarded its release. These results indicate possibility of different applications of SDs in pharmaceutical formulation, based on careful selection of the polymer co-former.

Druh

A - Audiovizuální tvorba

CEP obor

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OECD FORD obor

30104 - Pharmacology and pharmacy

Projekt

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Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

ISBN

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Místo vydání

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Název nakladatele resp. objednatele

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Verze

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Identifikační číslo nosiče

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