Quantifying the effect of fillers on the breakage behaviour of needle-shaped particles

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43901969" target="_blank" >RIV/60461373:22340/16:43901969 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.apt.2016.03.018" target="_blank" >http://dx.doi.org/10.1016/j.apt.2016.03.018</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.apt.2016.03.018" target="_blank" >10.1016/j.apt.2016.03.018</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantifying the effect of fillers on the breakage behaviour of needle-shaped particles

Popis výsledku v původním jazyce

Understanding the relationship between the applied stress and the behaviour of packings of breakable granular particles is required in many chemical engineering applications. A pharmaceutical tablet is an example where a composite packing (a packing containing a mixture of several kinds of particles) is compacted in the process of tablet formation. In this work, the unidirectional compaction and the breakage processes in composite packings formed from a mixture of breakable needle-shaped crystals and elastic spherical filler particles were studied using a Discrete Element Method (DEM) simulation. The evolution of crystal size distribution and contacts topology with the increasing stress was computed for different relative size, volume fraction and elasticity of filler particles inside the packing. We show that crystals breakability in a packing is directly related to the number of contacts among particles and that it can be significantly influenced by an appropriate choice of added filler particles. The results can be used for the development of mathematical models that describe the pharmaceutical tablet production and other processes involving composite packings of fragile particles.

Název v anglickém jazyce

Quantifying the effect of fillers on the breakage behaviour of needle-shaped particles

Popis výsledku anglicky

Understanding the relationship between the applied stress and the behaviour of packings of breakable granular particles is required in many chemical engineering applications. A pharmaceutical tablet is an example where a composite packing (a packing containing a mixture of several kinds of particles) is compacted in the process of tablet formation. In this work, the unidirectional compaction and the breakage processes in composite packings formed from a mixture of breakable needle-shaped crystals and elastic spherical filler particles were studied using a Discrete Element Method (DEM) simulation. The evolution of crystal size distribution and contacts topology with the increasing stress was computed for different relative size, volume fraction and elasticity of filler particles inside the packing. We show that crystals breakability in a packing is directly related to the number of contacts among particles and that it can be significantly influenced by an appropriate choice of added filler particles. The results can be used for the development of mathematical models that describe the pharmaceutical tablet production and other processes involving composite packings of fragile particles.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/GA15-05534S" target="_blank" >GA15-05534S: Studie vztahu mezi strukturou a vlastnostmi složitých granulárních systémů a dynamiky jejich lámání</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Advanced Powder Technology

ISSN

0921-8831

e-ISSN

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Svazek periodika

27

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

1093-1100

Kód UT WoS článku

000383357200007

EID výsledku v databázi Scopus

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