Complex traveling wave phenomena mediated by the coupling of phosphorylation cascades and extracellular diffusion in cellular populations

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F16%3A43902406" target="_blank" >RIV/60461373:22340/16:43902406 - isvavai.cz</a>

Výsledek na webu

<a href="http://www3.aiche.org/proceedings/Abstract.aspx?ConfID=Annual-2016&GroupID=2160&SessionID=32313&PaperID=462800" target="_blank" >http://www3.aiche.org/proceedings/Abstract.aspx?ConfID=Annual-2016&GroupID=2160&SessionID=32313&PaperID=462800</a>

DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Complex traveling wave phenomena mediated by the coupling of phosphorylation cascades and extracellular diffusion in cellular populations

Popis výsledku v původním jazyce

Here we will present a possible mechanism that can serve for the propagation of specific MAPK activity in cellular populations. The intracellular MAPK subnetwork is coupled with ligand-receptor signaling processes in our model. Spatially one dimensional extracellular domain that allows for ligand diffusion, ligand release and ligand interaction with membrane receptors is considered. Ligand-receptor complexes formed on the cytosolic membrane represents an input to the MAPK cascade. It is assumed that a double-phosphorylated kinase of MAPK cascade activates a specific protease responsible for the ligand release into extracellular space and thus closes a feedback loop. We will show that this coupling leads to the coexistence of one, two or three different steady states, or to the coexistence of a stable steady state and periodic solution. We systematically study the behavior of two identical cellular populations at the place of their contact. These populations differ only by initial conditions that are expressed as a particular stable steady state or periodic regime. We have found that traveling waves of MAPK activity typically appear at the place of contact. The propagation velocities and character strongly depend on the selected initial states of the two populations. The results of our systematic study and classification of the propagating waves will be presented.

Název v anglickém jazyce

Complex traveling wave phenomena mediated by the coupling of phosphorylation cascades and extracellular diffusion in cellular populations

Popis výsledku anglicky

Here we will present a possible mechanism that can serve for the propagation of specific MAPK activity in cellular populations. The intracellular MAPK subnetwork is coupled with ligand-receptor signaling processes in our model. Spatially one dimensional extracellular domain that allows for ligand diffusion, ligand release and ligand interaction with membrane receptors is considered. Ligand-receptor complexes formed on the cytosolic membrane represents an input to the MAPK cascade. It is assumed that a double-phosphorylated kinase of MAPK cascade activates a specific protease responsible for the ligand release into extracellular space and thus closes a feedback loop. We will show that this coupling leads to the coexistence of one, two or three different steady states, or to the coexistence of a stable steady state and periodic solution. We systematically study the behavior of two identical cellular populations at the place of their contact. These populations differ only by initial conditions that are expressed as a particular stable steady state or periodic regime. We have found that traveling waves of MAPK activity typically appear at the place of contact. The propagation velocities and character strongly depend on the selected initial states of the two populations. The results of our systematic study and classification of the propagating waves will be presented.

Druh

D - Stať ve sborníku

CEP obor

CI - Průmyslová chemie a chemické inženýrství

OECD FORD obor

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Projekt

<a href="/cs/project/LH14009" target="_blank" >LH14009: Nestability a dynamika funkčních motivů v biochemických sítích</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2016

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název statě ve sborníku

AIChE 2016 Annual Meeting

ISBN

978-0-8169-1097-7

ISSN

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e-ISSN

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Počet stran výsledku

22

Strana od-do

"398h-1"-"398h-22"

Název nakladatele

American Institute of Chemical Engineers (AIChE)

Místo vydání

New York

Místo konání akce

San Francisco

Datum konání akce

13. 11. 2016

Typ akce podle státní příslušnosti

WRD - Celosvětová akce

Kód UT WoS článku

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