Development of artificial garlic cell aimed for superficial applications

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F19%3A43919661" target="_blank" >RIV/60461373:22340/19:43919661 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Development of artificial garlic cell aimed for superficial applications

Popis výsledku v původním jazyce

The aim of this work is to produce a drug carrier inspired by the most famous natural self-defence system – garlic. Garlic (Allium sativum) has been well-known for thousands of years for its beneficial properties and healing powers. The favourable effects are attributed mainly to the sulfur-containing volatile substance called allicin. Allicin is produced enzymatically from the stable precursor (alliin) when inner cell structure is compromised (e.g. by cutting). However, high reactivity, volatility and very short half-time make allicin unfavourable for practical application, i.e. short shelf life, spontaneous decomposition and pungent garlic smell. However, at the same time, a short half time compared to conventional antibiotics is the reason why allicin is much more resilient to the development of bacterial resistance. We propose an artificial carrier where both enzyme and alliin are separated and stabilized. Allicin production will be then triggered only when needed upon contact with water. Encapsulation techniques such as spray drying, and ionic gelation will be employed, and antibacterial potential of garlic-based carriers will be demonstrated.

Název v anglickém jazyce

Development of artificial garlic cell aimed for superficial applications

Popis výsledku anglicky

The aim of this work is to produce a drug carrier inspired by the most famous natural self-defence system – garlic. Garlic (Allium sativum) has been well-known for thousands of years for its beneficial properties and healing powers. The favourable effects are attributed mainly to the sulfur-containing volatile substance called allicin. Allicin is produced enzymatically from the stable precursor (alliin) when inner cell structure is compromised (e.g. by cutting). However, high reactivity, volatility and very short half-time make allicin unfavourable for practical application, i.e. short shelf life, spontaneous decomposition and pungent garlic smell. However, at the same time, a short half time compared to conventional antibiotics is the reason why allicin is much more resilient to the development of bacterial resistance. We propose an artificial carrier where both enzyme and alliin are separated and stabilized. Allicin production will be then triggered only when needed upon contact with water. Encapsulation techniques such as spray drying, and ionic gelation will be employed, and antibacterial potential of garlic-based carriers will be demonstrated.

Druh

O - Ostatní výsledky

CEP obor

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OECD FORD obor

20402 - Chemical process engineering

Projekt

<a href="/cs/project/TJ01000313" target="_blank" >TJ01000313: Vývoj biomimetických částic pro antibakteriální aplikace</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2019

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů