Comparison between two multicomponent drug delivery systems based on PEGylated-poly (L-lactide-co-glycolide) and superparamagnetic nanoparticles: Nanoparticulate versus nanocluster systems

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922855" target="_blank" >RIV/60461373:22340/21:43922855 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/21:43922855 RIV/70883521:28610/21:63543238

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S1773224721003233?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S1773224721003233?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jddst.2021.102643" target="_blank" >10.1016/j.jddst.2021.102643</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Comparison between two multicomponent drug delivery systems based on PEGylated-poly (L-lactide-co-glycolide) and superparamagnetic nanoparticles: Nanoparticulate versus nanocluster systems

Popis výsledku v původním jazyce

Development of versatile and efficient multicomponent drug delivery nanocarriers in the range of hundreds of nanometers in size with tunable surface properties presents an interesting platform for biomedical applications. In this study, two approaches were evaluated for preparation of multi-component drug delivery nanocarriers based on the assembly of drug loaded PEGylated poly(L-lactide-co-glycolide) nanoparticles (PEGylated PLGA NPs) and superparamagnetic iron oxide nanoparticles (IO NPs). In the first approach, preparation of nanoclusters was performed by self-assembly of oppositely charged ibuprofen loaded PEGylated-PLGA and IO NPs, while in the second one IO NPs and a model drug (ibuprofen) were incorporated inside PEGylated PLGA NPs by single emulsion method. Nanoclusters as well as multi-component loaded PEGylated PLGA NPs with a size of 350 ± 71 nm and 238 ± 88 nm, respectively, were produced. Interestingly, both delivery systems demonstrated comparable drug release behavior after 120 h. They exhibited also comparable magnetic properties before and after dissolution tests. Mechanistic insights into the effect of the morphology and chemical composition of the multi-component delivery systems on the drug release mechanisms are proposed. © 2021 Elsevier B.V.

Název v anglickém jazyce

Comparison between two multicomponent drug delivery systems based on PEGylated-poly (L-lactide-co-glycolide) and superparamagnetic nanoparticles: Nanoparticulate versus nanocluster systems

Popis výsledku anglicky

Development of versatile and efficient multicomponent drug delivery nanocarriers in the range of hundreds of nanometers in size with tunable surface properties presents an interesting platform for biomedical applications. In this study, two approaches were evaluated for preparation of multi-component drug delivery nanocarriers based on the assembly of drug loaded PEGylated poly(L-lactide-co-glycolide) nanoparticles (PEGylated PLGA NPs) and superparamagnetic iron oxide nanoparticles (IO NPs). In the first approach, preparation of nanoclusters was performed by self-assembly of oppositely charged ibuprofen loaded PEGylated-PLGA and IO NPs, while in the second one IO NPs and a model drug (ibuprofen) were incorporated inside PEGylated PLGA NPs by single emulsion method. Nanoclusters as well as multi-component loaded PEGylated PLGA NPs with a size of 350 ± 71 nm and 238 ± 88 nm, respectively, were produced. Interestingly, both delivery systems demonstrated comparable drug release behavior after 120 h. They exhibited also comparable magnetic properties before and after dissolution tests. Mechanistic insights into the effect of the morphology and chemical composition of the multi-component delivery systems on the drug release mechanisms are proposed. © 2021 Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Drug Delivery Science and Technology

ISSN

1773-2247

e-ISSN

—

Svazek periodika

64

Číslo periodika v rámci svazku

AUG 2021

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

11

Strana od-do

102643

Kód UT WoS článku

000674469000008

EID výsledku v databázi Scopus

2-s2.0-85107661356