Self-assembly of poly(L-lactide-co-glycolide) and magnetic nanoparticles into nanoclusters for controlled drug delivery

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F70883521%3A28610%2F20%3A63526489" target="_blank" >RIV/70883521:28610/20:63526489 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22310/20:43921236 RIV/60461373:22340/20:43921236

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0014305720304523" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0014305720304523</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.eurpolymj.2020.109795" target="_blank" >10.1016/j.eurpolymj.2020.109795</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Self-assembly of poly(L-lactide-co-glycolide) and magnetic nanoparticles into nanoclusters for controlled drug delivery

Popis výsledku v původním jazyce

The possibility to combine nanoparticles (NPs) with different functionalities into nanoclusters of controlled size and kinetic profile of drug release presents a promising route for the preparation of a multifunctional drug delivery system. In this study, to construct controlled drug delivery (nano)clusters, a simple and versatile method based on self-assembly via electrostatic interactions of oppositely charged poly(lactide-co-glycolide) (PLGA) and superparamagnetic iron oxide (IO) NPs was developed. Drug loaded heteroclusters with controlled size of 224 ± 52 nm and Zeta potential of −51 ± 6 mV were produced. Dissolution tests demonstrated an accelerated drug release in the heteroclusters compared to neat PLGA NPs after 24 h. This was correlated with the catalytic effect of IO NPs on the degradation of PLGA matrix. Moreover, the magnetic properties of the heteroclusters were maintained after the dissolution tests. Hence, even after drug release, the heteroclusters can be used for treatment with magnetically mediated hyperthermia.

Název v anglickém jazyce

Self-assembly of poly(L-lactide-co-glycolide) and magnetic nanoparticles into nanoclusters for controlled drug delivery

Popis výsledku anglicky

The possibility to combine nanoparticles (NPs) with different functionalities into nanoclusters of controlled size and kinetic profile of drug release presents a promising route for the preparation of a multifunctional drug delivery system. In this study, to construct controlled drug delivery (nano)clusters, a simple and versatile method based on self-assembly via electrostatic interactions of oppositely charged poly(lactide-co-glycolide) (PLGA) and superparamagnetic iron oxide (IO) NPs was developed. Drug loaded heteroclusters with controlled size of 224 ± 52 nm and Zeta potential of −51 ± 6 mV were produced. Dissolution tests demonstrated an accelerated drug release in the heteroclusters compared to neat PLGA NPs after 24 h. This was correlated with the catalytic effect of IO NPs on the degradation of PLGA matrix. Moreover, the magnetic properties of the heteroclusters were maintained after the dissolution tests. Hence, even after drug release, the heteroclusters can be used for treatment with magnetically mediated hyperthermia.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10404 - Polymer science

Projekt

<a href="/cs/project/NV16-34342A" target="_blank" >NV16-34342A: Multifunkční nanoclustery jako platforma pro cílené doručování léčiv</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

European Polymer Journal

ISSN

0014-3057

e-ISSN

—

Svazek periodika

133

Číslo periodika v rámci svazku

Neuveden

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000549179400006

EID výsledku v databázi Scopus

2-s2.0-85085490935