Optimization of Wurster fluid bed coating: Mathematical model validated against pharmaceutical production data

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43922885" target="_blank" >RIV/60461373:22340/21:43922885 - isvavai.cz</a>

Výsledek na webu

<a href="https://doi.org/10.1016/j.powtec.2021.03.059" target="_blank" >https://doi.org/10.1016/j.powtec.2021.03.059</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2021.03.059" target="_blank" >10.1016/j.powtec.2021.03.059</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Optimization of Wurster fluid bed coating: Mathematical model validated against pharmaceutical production data

Popis výsledku v původním jazyce

Wurster fluid bed coating is an effective way of manufacturing pharmaceutical pellets requiring specific characteristics such as high drug loading or enteric protection. The optimization of coating process can be demanding because it necessitates many time-consuming experiments. To reduce the need for experiments and prevent undesired agglomeration, a multi-scale model has been developed. On the device-scale, the model predicts the temperature, moisture content, and average coating thickness. On the micro-scale, the model estimates the evaporation time of a single sessile droplet. By coupling models at both length-scales, it is possible to evaluate droplet evaporation time as a function of process parameters and use it as a tool for process transfer between different production sites and equipment. The model was validated against existing production data. The predicted outlet air temperature was in good agreement, and most importantly, the predicted values of the evaporation time separated undesired agglomeration and successful coating regime. © 2021 Elsevier B.V.

Název v anglickém jazyce

Optimization of Wurster fluid bed coating: Mathematical model validated against pharmaceutical production data

Popis výsledku anglicky

Wurster fluid bed coating is an effective way of manufacturing pharmaceutical pellets requiring specific characteristics such as high drug loading or enteric protection. The optimization of coating process can be demanding because it necessitates many time-consuming experiments. To reduce the need for experiments and prevent undesired agglomeration, a multi-scale model has been developed. On the device-scale, the model predicts the temperature, moisture content, and average coating thickness. On the micro-scale, the model estimates the evaporation time of a single sessile droplet. By coupling models at both length-scales, it is possible to evaluate droplet evaporation time as a function of process parameters and use it as a tool for process transfer between different production sites and equipment. The model was validated against existing production data. The predicted outlet air temperature was in good agreement, and most importantly, the predicted values of the evaporation time separated undesired agglomeration and successful coating regime. © 2021 Elsevier B.V.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

<a href="/cs/project/GX19-26127X" target="_blank" >GX19-26127X: Robotický nano-lékárník: Výrobní procesy budoucnosti pro personalisovaná terapeutika</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Powder Technology

ISSN

0032-5910

e-ISSN

—

Svazek periodika

386

Číslo periodika v rámci svazku

July 2021

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

14

Strana od-do

505-518

Kód UT WoS článku

000648647700006

EID výsledku v databázi Scopus

2-s2.0-85104152478