Effects of workers exposure to nanoparticles studied by nmr metabolomics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F21%3A43934149" target="_blank" >RIV/60461373:22340/21:43934149 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/67985858:_____/21:00544564 RIV/46747885:24210/21:00009176 RIV/00216208:11110/21:10429727 RIV/00064165:_____/21:10429727

Výsledek na webu

<a href="https://doi.org/10.3390/app11146601" target="_blank" >https://doi.org/10.3390/app11146601</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/app11146601" target="_blank" >10.3390/app11146601</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Effects of workers exposure to nanoparticles studied by nmr metabolomics

Popis výsledku v původním jazyce

In this study, the effects of occupational exposure to nanoparticles (NPs) were studied by NMR metabolomics. Exhaled breath condensate (EBC) and blood plasma samples were obtained from a research nanoparticles-processing unit at a national research university. The samples were taken from three groups of subjects: samples from workers exposed to nanoparticles collected before and after shift, and from controls not exposed to NPs. Altogether, 601H NMR spectra of exhaled breath condensate (EBC) samples and 601H NMR spectra of blood plasma samples were analysed, 20 in each group. The metabolites identified together with binning data were subjected to multivariate statistical analysis, which provided clear discrimination of the groups studied. Statistically sig-nificant metabolites responsible for group separation served as a foundation for analysis of im-paired metabolic pathways. It was found that the acute effect of NPs exposure is mainly reflected in the pathways related to the production of antioxidants and other protective species, while the chronic effect is manifested mainly in the alteration of glutamine and glutamate metabolism, and the purine metabolism pathway.

Název v anglickém jazyce

Effects of workers exposure to nanoparticles studied by nmr metabolomics

Popis výsledku anglicky

In this study, the effects of occupational exposure to nanoparticles (NPs) were studied by NMR metabolomics. Exhaled breath condensate (EBC) and blood plasma samples were obtained from a research nanoparticles-processing unit at a national research university. The samples were taken from three groups of subjects: samples from workers exposed to nanoparticles collected before and after shift, and from controls not exposed to NPs. Altogether, 601H NMR spectra of exhaled breath condensate (EBC) samples and 601H NMR spectra of blood plasma samples were analysed, 20 in each group. The metabolites identified together with binning data were subjected to multivariate statistical analysis, which provided clear discrimination of the groups studied. Statistically sig-nificant metabolites responsible for group separation served as a foundation for analysis of im-paired metabolic pathways. It was found that the acute effect of NPs exposure is mainly reflected in the pathways related to the production of antioxidants and other protective species, while the chronic effect is manifested mainly in the alteration of glutamine and glutamate metabolism, and the purine metabolism pathway.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10400 - Chemical sciences

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Applied Sciences-Basel

ISSN

2076-3417

e-ISSN

2076-3417

Svazek periodika

11

Číslo periodika v rámci svazku

14

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

18

Strana od-do

nestránkováno

Kód UT WoS článku

000675931400001

EID výsledku v databázi Scopus

2-s2.0-85111257168