Electrochemically deposited cobalt bis(dicarbollide) derivative and the detection of neuroblastoma markers on the electrode surface

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43923963" target="_blank" >RIV/60461373:22340/22:43923963 - isvavai.cz</a>

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S157266572200666X?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S157266572200666X?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jelechem.2022.116674" target="_blank" >10.1016/j.jelechem.2022.116674</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Electrochemically deposited cobalt bis(dicarbollide) derivative and the detection of neuroblastoma markers on the electrode surface

Popis výsledku v původním jazyce

A cobalt bis(dicarbollide) derivative deposited onto the surface of a graphite electrode through an electrochemically oxidized o-phenylenediamine unit (pCB-oPD) is proposed for the detection of catecholamine metabolites, namely homovanillic acid (HVA) and vanillylmandelic acid (VMA). These metabolites are diagnostic markers of neuroblastoma. The set of electrochemical techniques, electrochemical impedance spectroscopy (EIS), potentiometry, and differential pulse voltammetry (DPV), makes it possible to evaluate the options of the individual and simultaneous detection of metabolites. The values of association constants that were found between the pCB-oPD attached to the electrode surface and the metabolites showed a high affinity to HVA (2.5 × 105) compared to VMA (4.3 × 104). The binding of the metabolites to the pCB-oPD-modified electrode allows the differentiation of VMA and HVA in the mixture, which can be of practical interest.

Název v anglickém jazyce

Electrochemically deposited cobalt bis(dicarbollide) derivative and the detection of neuroblastoma markers on the electrode surface

Popis výsledku anglicky

A cobalt bis(dicarbollide) derivative deposited onto the surface of a graphite electrode through an electrochemically oxidized o-phenylenediamine unit (pCB-oPD) is proposed for the detection of catecholamine metabolites, namely homovanillic acid (HVA) and vanillylmandelic acid (VMA). These metabolites are diagnostic markers of neuroblastoma. The set of electrochemical techniques, electrochemical impedance spectroscopy (EIS), potentiometry, and differential pulse voltammetry (DPV), makes it possible to evaluate the options of the individual and simultaneous detection of metabolites. The values of association constants that were found between the pCB-oPD attached to the electrode surface and the metabolites showed a high affinity to HVA (2.5 × 105) compared to VMA (4.3 × 104). The binding of the metabolites to the pCB-oPD-modified electrode allows the differentiation of VMA and HVA in the mixture, which can be of practical interest.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10406 - Analytical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF ELECTROANALYTICAL CHEMISTRY

ISSN

1572-6657

e-ISSN

1873-2569

Svazek periodika

921

Číslo periodika v rámci svazku

15 September 2022

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

7

Strana od-do

116674

Kód UT WoS článku

000861235700005

EID výsledku v databázi Scopus

2-s2.0-85135855737