Impact of crystallization conditions and filtration cake washing on the clustering of metformin hydrochloride crystals

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43925024" target="_blank" >RIV/60461373:22340/22:43925024 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21110/22:00359037

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0032591022004168?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0032591022004168?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.powtec.2022.117522" target="_blank" >10.1016/j.powtec.2022.117522</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Impact of crystallization conditions and filtration cake washing on the clustering of metformin hydrochloride crystals

Popis výsledku v původním jazyce

Crystallization is one of the basic methods employed in the pharmaceutical and chemical industry to produce powder products with controlled purity. Crystallization is commonly associated with the filtration and drying of solid material, where these unit operations can significantly affect the properties of the final material. This study focuses on the interplay of crystallization, filtration, cake washing, and drying to prevent the formation of crystal clusters. In this work, metformin hydrochloride crystalizing in rod-like crystals is used as a model drug. First, the crystallization parameters, such as stirring speed, cooling rate, impeller type, and solvent type, were varied. It was found that in all cases, metformin hydrochloride crystalizes in single rod-like crystals with various crystal size distribution, where the cooling rate and solvent type lead to non-uniform crystal growth demonstrated by very polydisperse crystal size distribution. Experimental results and Computational Fluid Dynamics simulation confirmed that stresses during crystallization were not sufficient to cause significant crystal breakup. In the next step, filtration connected with filter cake washing and subsequent drying was used to study the formation of crystal clusters. It was found that crystal cake was significantly stronger for the non-washed samples than for washed cake. Both the measured apparent elasticity modulus and the apparent hardness confirmed a strong impact of the washing solvent, allowing quality control when developing a crystal production process.

Název v anglickém jazyce

Impact of crystallization conditions and filtration cake washing on the clustering of metformin hydrochloride crystals

Popis výsledku anglicky

Crystallization is one of the basic methods employed in the pharmaceutical and chemical industry to produce powder products with controlled purity. Crystallization is commonly associated with the filtration and drying of solid material, where these unit operations can significantly affect the properties of the final material. This study focuses on the interplay of crystallization, filtration, cake washing, and drying to prevent the formation of crystal clusters. In this work, metformin hydrochloride crystalizing in rod-like crystals is used as a model drug. First, the crystallization parameters, such as stirring speed, cooling rate, impeller type, and solvent type, were varied. It was found that in all cases, metformin hydrochloride crystalizes in single rod-like crystals with various crystal size distribution, where the cooling rate and solvent type lead to non-uniform crystal growth demonstrated by very polydisperse crystal size distribution. Experimental results and Computational Fluid Dynamics simulation confirmed that stresses during crystallization were not sufficient to cause significant crystal breakup. In the next step, filtration connected with filter cake washing and subsequent drying was used to study the formation of crystal clusters. It was found that crystal cake was significantly stronger for the non-washed samples than for washed cake. Both the measured apparent elasticity modulus and the apparent hardness confirmed a strong impact of the washing solvent, allowing quality control when developing a crystal production process.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20401 - Chemical engineering (plants, products)

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Powder Technology

ISSN

0032-5910

e-ISSN

1873-328X

Svazek periodika

405

Číslo periodika v rámci svazku

JUN 2022

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

11

Strana od-do

117522

Kód UT WoS článku

000809770800006

EID výsledku v databázi Scopus

2-s2.0-85130574864