Long-Term Averaged Spectrum Descriptors of Dysarthria in Patients With Parkinson’s Disease Treated With Subthalamic Nucleus Deep Brain Stimulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F22%3A43925514" target="_blank" >RIV/60461373:22340/22:43925514 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68407700:21230/22:00362584 RIV/00216208:11110/22:10456563 RIV/00064165:_____/22:10456563

Výsledek na webu

<a href="https://pubs.asha.org/doi/10.1044/2022_JSLHR-22-00308?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed" target="_blank" >https://pubs.asha.org/doi/10.1044/2022_JSLHR-22-00308?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1044/2022_JSLHR-22-00308" target="_blank" >10.1044/2022_JSLHR-22-00308</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Long-Term Averaged Spectrum Descriptors of Dysarthria in Patients With Parkinson’s Disease Treated With Subthalamic Nucleus Deep Brain Stimulation

Popis výsledku v původním jazyce

Purpose: This study aimed to evaluate whether long-term averaged spectrum (LTAS) descriptors for reading and monologue are suitable to detect worsening of dysarthria in patients with Parkinson’s disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) with potential effect of ON and OFF stimulation conditions and types of connected speech. Method: Four spectral moments based on LTAS were computed for monologue and reading passage collected from 23 individuals with PD treated with bilateral STN-DBS and 23 age-and gender-matched healthy controls. Speech performance of patients with PD was compared in ON and OFF STN-DBS conditions. Results: All LTAS spectral moments including mean, standard deviation, skew-ness, and kurtosis across both monologue and reading passage were able to significantly distinguish between patients with PD in both stimulation conditions and control speakers. The spectral mean was the only LTAS measure sensitive to capture better speech performance in STN-DBS ON, as compared to the STN-DBS OFF stimulation condition (p &lt; .05). Standardized reading passage was more sensitive compared to monologue in detecting dysarthria severity via LTAS descriptors with an area under the curve of up to 0.92 obtained between PD and control groups. Conclusions: Our findings confirmed that LTAS is a suitable approach to objec-tively describe changes in speech impairment severity due to STN-DBS therapy in patients with PD. We envisage these results as an important step toward a continuum development of technological solutions for the automated assessment of stimulation-induced dysarthria. Supplemental Material: https://doi.org/10.23641/asha.21644798. © 2022 American Speech-Language-Hearing Association.

Název v anglickém jazyce

Long-Term Averaged Spectrum Descriptors of Dysarthria in Patients With Parkinson’s Disease Treated With Subthalamic Nucleus Deep Brain Stimulation

Popis výsledku anglicky

Purpose: This study aimed to evaluate whether long-term averaged spectrum (LTAS) descriptors for reading and monologue are suitable to detect worsening of dysarthria in patients with Parkinson’s disease (PD) treated with subthalamic nucleus deep brain stimulation (STN-DBS) with potential effect of ON and OFF stimulation conditions and types of connected speech. Method: Four spectral moments based on LTAS were computed for monologue and reading passage collected from 23 individuals with PD treated with bilateral STN-DBS and 23 age-and gender-matched healthy controls. Speech performance of patients with PD was compared in ON and OFF STN-DBS conditions. Results: All LTAS spectral moments including mean, standard deviation, skew-ness, and kurtosis across both monologue and reading passage were able to significantly distinguish between patients with PD in both stimulation conditions and control speakers. The spectral mean was the only LTAS measure sensitive to capture better speech performance in STN-DBS ON, as compared to the STN-DBS OFF stimulation condition (p &lt; .05). Standardized reading passage was more sensitive compared to monologue in detecting dysarthria severity via LTAS descriptors with an area under the curve of up to 0.92 obtained between PD and control groups. Conclusions: Our findings confirmed that LTAS is a suitable approach to objec-tively describe changes in speech impairment severity due to STN-DBS therapy in patients with PD. We envisage these results as an important step toward a continuum development of technological solutions for the automated assessment of stimulation-induced dysarthria. Supplemental Material: https://doi.org/10.23641/asha.21644798. © 2022 American Speech-Language-Hearing Association.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20601 - Medical engineering

Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

V - Vyzkumna aktivita podporovana z jinych verejnych zdroju

Rok uplatnění

2022

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Speech, Language, and Hearing Research

ISSN

1092-4388

e-ISSN

1558-9102

Svazek periodika

65

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

10

Strana od-do

4690-4699

Kód UT WoS článku

000931940600012

EID výsledku v databázi Scopus

2-s2.0-85143888537