Finding low-toxicity biopolymer solvents with high melting temperature and thermally induced phase separation of poly(ε-caprolactone)

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F60461373%3A22340%2F24%3A43930124" target="_blank" >RIV/60461373:22340/24:43930124 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubs.rsc.org/en/content/articlelanding/2024/ma/d4ma01033g" target="_blank" >https://pubs.rsc.org/en/content/articlelanding/2024/ma/d4ma01033g</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/D4MA01033G" target="_blank" >10.1039/D4MA01033G</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Finding low-toxicity biopolymer solvents with high melting temperature and thermally induced phase separation of poly(ε-caprolactone)

Popis výsledku v původním jazyce

This study focuses on identifying low-toxicity solvents for biopolymers such as poly(ε-caprolactone) (PCL) and polylactic acid (PLA) for applications inthermally induced phase separation (TIPS). Common solvents like dioxane and tetrahydrofuran, despite their effectivity, pose significant health risks.Therefore, this research aims to expand the available knowledge of safer solvent alternatives with melting temperatures above 0°C to enhance the economicand environmental viability of TIPS. The Hansen solubility theory was applied to screen 846 chemicals for their compatibility with biopolymers, selectingthose with favourable properties and experimentally testing their potential as TIPS solvents. Among the newly identified solvents, methyl-p-toluate (MPTOL)exhibited superior performance for PCL, showing high dissolution efficiency, low toxicity, and a melting temperature of 34°C. The phase diagram of thePCL/MPTOL system was constructed using experimental data and computational modelling based on Flory-Huggins theory and PC-SAFT equation of state.Foams prepared through TIPS from this system demonstrated three distinct morphologies with increasing PCL concentration, aligning with expectationsbased on the phase diagram. These findings present methyl-p-toluate as a promising, safer alternative solvent for biopolymer processing in tissueengineering and membrane technologies, with potential to reduce energy costs and enhance process efficiency.

Název v anglickém jazyce

Finding low-toxicity biopolymer solvents with high melting temperature and thermally induced phase separation of poly(ε-caprolactone)

Popis výsledku anglicky

This study focuses on identifying low-toxicity solvents for biopolymers such as poly(ε-caprolactone) (PCL) and polylactic acid (PLA) for applications inthermally induced phase separation (TIPS). Common solvents like dioxane and tetrahydrofuran, despite their effectivity, pose significant health risks.Therefore, this research aims to expand the available knowledge of safer solvent alternatives with melting temperatures above 0°C to enhance the economicand environmental viability of TIPS. The Hansen solubility theory was applied to screen 846 chemicals for their compatibility with biopolymers, selectingthose with favourable properties and experimentally testing their potential as TIPS solvents. Among the newly identified solvents, methyl-p-toluate (MPTOL)exhibited superior performance for PCL, showing high dissolution efficiency, low toxicity, and a melting temperature of 34°C. The phase diagram of thePCL/MPTOL system was constructed using experimental data and computational modelling based on Flory-Huggins theory and PC-SAFT equation of state.Foams prepared through TIPS from this system demonstrated three distinct morphologies with increasing PCL concentration, aligning with expectationsbased on the phase diagram. These findings present methyl-p-toluate as a promising, safer alternative solvent for biopolymer processing in tissueengineering and membrane technologies, with potential to reduce energy costs and enhance process efficiency.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

20501 - Materials engineering

Projekt

—

Návaznosti

S - Specificky vyzkum na vysokych skolach

Rok uplatnění

2024

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Materials Advances

ISSN

2633-5409

e-ISSN

2633-5409

Svazek periodika

Neuveden

Číslo periodika v rámci svazku

Listopad

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

17

Strana od-do

1-17

Kód UT WoS článku

001369381900001

EID výsledku v databázi Scopus

—