Surface Microdialysis for Detection of Colorectal Surface Microdialysis for Detection of Colorectal

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61383082%3A_____%2F21%3A00001051" target="_blank" >RIV/61383082:_____/21:00001051 - isvavai.cz</a>

Výsledek na webu

<a href="https://pubmed.ncbi.nlm.nih.gov/33477078/" target="_blank" >https://pubmed.ncbi.nlm.nih.gov/33477078/</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jss.2020.12.021" target="_blank" >10.1016/j.jss.2020.12.021</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Surface Microdialysis for Detection of Colorectal Surface Microdialysis for Detection of Colorectal

Popis výsledku v původním jazyce

Background: Inadequate blood supply is one of the major risk factors for anastomotic leak after low anterior rectal resection. Early detection of ischemia might predict complicated healing and enable anastomotic salvage, which is associated with better outcomes. A microdialysis offers a real-time evaluation of adequate bowel perfusion through moni toring of tissue metabolism. In this experimental study, we assessed the role of micro dialysis in detecting early ischemia after colorectal anastomosis.Materials and methods: Colorectal anastomosis was performed in six miniature pigs. A microdialysis catheter was placed on the bowel serosa 5 mm proximal to the anastomosis. Metabolic changes were monitored hourly before and after initiating ischemia, which was induced by ligation of the inferior mesenteric artery and skeletonization of the mesocolon. Results: Significant increase in tissue levels of lactate was detected after 60 min of ischemia (13.6 [10.4-16.1] versus 6.75 [1.8-9.6] mmol/L at baseline; P < 0.005). The lactate/pyruvate ratio increased accordingly. The concentration of glycerol increased significantly after 2 hoursdfrom a baseline value of 29.5 (3-84) to 125 (79-201) mmol/L (P < 0.005). The decrease in glucose levels was also significant after 60 minutesd0 (0-0.2) versus 4.7 (3.3-6.8) mmol/L at baseline. However, its values started to decline before ischemia. Conclusions: Surface microdialysis can detect ischemic changes early and may be a prom ising method in postoperative monitoring of colorectal anastomosis

Název v anglickém jazyce

Surface Microdialysis for Detection of Colorectal Surface Microdialysis for Detection of Colorectal

Popis výsledku anglicky

Background: Inadequate blood supply is one of the major risk factors for anastomotic leak after low anterior rectal resection. Early detection of ischemia might predict complicated healing and enable anastomotic salvage, which is associated with better outcomes. A microdialysis offers a real-time evaluation of adequate bowel perfusion through moni toring of tissue metabolism. In this experimental study, we assessed the role of micro dialysis in detecting early ischemia after colorectal anastomosis.Materials and methods: Colorectal anastomosis was performed in six miniature pigs. A microdialysis catheter was placed on the bowel serosa 5 mm proximal to the anastomosis. Metabolic changes were monitored hourly before and after initiating ischemia, which was induced by ligation of the inferior mesenteric artery and skeletonization of the mesocolon. Results: Significant increase in tissue levels of lactate was detected after 60 min of ischemia (13.6 [10.4-16.1] versus 6.75 [1.8-9.6] mmol/L at baseline; P < 0.005). The lactate/pyruvate ratio increased accordingly. The concentration of glycerol increased significantly after 2 hoursdfrom a baseline value of 29.5 (3-84) to 125 (79-201) mmol/L (P < 0.005). The decrease in glucose levels was also significant after 60 minutesd0 (0-0.2) versus 4.7 (3.3-6.8) mmol/L at baseline. However, its values started to decline before ischemia. Conclusions: Surface microdialysis can detect ischemic changes early and may be a prom ising method in postoperative monitoring of colorectal anastomosis

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

30212 - Surgery

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2021

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

JOURNAL OF SURGICAL RESEARCH

ISSN

0022-4804

e-ISSN

—

Svazek periodika

261

Číslo periodika v rámci svazku

May

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

8

Strana od-do

293-300

Kód UT WoS článku

000635161100037

EID výsledku v databázi Scopus

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