Hmotnostní spektrometrie v proudové trubici s vybranými ionty (SIFT-MS) kyseliny 3-hydroxymáselné, acetonu a dalších ketonů ve výparech vodných roztoků

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F08%3A00314991" target="_blank" >RIV/61388955:_____/08:00314991 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Selected ion flow tube mass spectrometry of 3-hydroxybutyric acid, acetone and other ketones in the headspace of aqueous solution and urine

Popis výsledku v původním jazyce

A study has been carried out of the reactions of three isomers of hydroxybutyric acid, giving special attention to 3-hydroxybutyric acid, 3-HBA, with H3O+ and NO+ ions to acquire the required kinetic data for a selected ion flow tube mass spectrometry, SIFT-MS, search for 3-HBA in the headspace of urine since it is known to be one of the "ketone bodies" important in the diagnosis of ketoacidosis. Thus, the product ions formed in the reactions of the H3O+ and NO+ precursor ions with the three hydroxy acids were established by sampling the headspace above the pure compounds over a range of absolute humidities from 1.5% (ambient air) to 6% (liquid headspace at 37 C and exhaled breath). Then these data, together with the rate coefficients for the reactionsestimated by calculation, were used to detect and quantify 3-HBA in the headspace of an aqueous solution of this compound of known concentration and above urine donated by two volunteers.

Název v anglickém jazyce

Selected ion flow tube mass spectrometry of 3-hydroxybutyric acid, acetone and other ketones in the headspace of aqueous solution and urine

Popis výsledku anglicky

A study has been carried out of the reactions of three isomers of hydroxybutyric acid, giving special attention to 3-hydroxybutyric acid, 3-HBA, with H3O+ and NO+ ions to acquire the required kinetic data for a selected ion flow tube mass spectrometry, SIFT-MS, search for 3-HBA in the headspace of urine since it is known to be one of the "ketone bodies" important in the diagnosis of ketoacidosis. Thus, the product ions formed in the reactions of the H3O+ and NO+ precursor ions with the three hydroxy acids were established by sampling the headspace above the pure compounds over a range of absolute humidities from 1.5% (ambient air) to 6% (liquid headspace at 37 C and exhaled breath). Then these data, together with the rate coefficients for the reactionsestimated by calculation, were used to detect and quantify 3-HBA in the headspace of an aqueous solution of this compound of known concentration and above urine donated by two volunteers.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA202%2F06%2F0776" target="_blank" >GA202/06/0776: Pokročilý výzkum a vývoj zdrojů nízkoteplotního plazmatu</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2008

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Mass Spectrometry

ISSN

1387-3806

e-ISSN

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Svazek periodika

272

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

8

Strana od-do

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Kód UT WoS článku

000254785000009

EID výsledku v databázi Scopus

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