METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F11%3A00371757" target="_blank" >RIV/61388955:_____/11:00371757 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1135/cccc2011113" target="_blank" >http://dx.doi.org/10.1135/cccc2011113</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1135/cccc2011113" target="_blank" >10.1135/cccc2011113</a>

Jazyk výsledku

angličtina

Název v původním jazyce

METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY

Popis výsledku v původním jazyce

Radiosensitizers belong to the most important class of the cancerostatic drugs. The electrochemical transfer of the first electron to the cytotoxic radiosensitizer Metronidazole (MET) and MET radical anion formation in aprotic medium was studied by meansof electrochemical impedance spectroscopy. The heterogeneous electron transfer rate constant for the first reduction of MET (radical anion production) k0 for the redox couple was determined. Similarly, the diffusion coefficient of MET in dimethylformamide was also calculated by impedance measurements using expression for Warburg coefficient and Warburg plot. Moreover, the equivalent circuit for the redox couple MET/MET? was proposed and its parameters were evaluated using a non-linear least square fitting. Our results, from the electrochemical point of view, also confirm the suitability of MET for the effective treatment of selected types of the cancer.

Název v anglickém jazyce

METRONIDAZOLE RADICAL ANION FORMATION STUDIED BY MEANS OF ELECTROCHEMICAL IMPEDANCE SPECTROSCOPY

Popis výsledku anglicky

Radiosensitizers belong to the most important class of the cancerostatic drugs. The electrochemical transfer of the first electron to the cytotoxic radiosensitizer Metronidazole (MET) and MET radical anion formation in aprotic medium was studied by meansof electrochemical impedance spectroscopy. The heterogeneous electron transfer rate constant for the first reduction of MET (radical anion production) k0 for the redox couple was determined. Similarly, the diffusion coefficient of MET in dimethylformamide was also calculated by impedance measurements using expression for Warburg coefficient and Warburg plot. Moreover, the equivalent circuit for the redox couple MET/MET? was proposed and its parameters were evaluated using a non-linear least square fitting. Our results, from the electrochemical point of view, also confirm the suitability of MET for the effective treatment of selected types of the cancer.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CG - Elektrochemie

OECD FORD obor

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Projekt

Výsledek vznikl pri realizaci vícero projektů. Více informací v záložce Projekty.

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2011

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Collection of Czechoslovak Chemical Communications

ISSN

0010-0765

e-ISSN

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Svazek periodika

76

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CZ - Česká republika

Počet stran výsledku

11

Strana od-do

1607-1617

Kód UT WoS článku

000299816100013

EID výsledku v databázi Scopus

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