A Multi Time-Scale Approach of the Lipid Bilayer Dynamics

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F12%3A00377702" target="_blank" >RIV/61388955:_____/12:00377702 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1016/B978-0-12-396533-2.00002-1" target="_blank" >http://dx.doi.org/10.1016/B978-0-12-396533-2.00002-1</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/B978-0-12-396533-2.00002-1" target="_blank" >10.1016/B978-0-12-396533-2.00002-1</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A Multi Time-Scale Approach of the Lipid Bilayer Dynamics

Popis výsledku v původním jazyce

The lipid bilayer is a supramolecular aggregate with complex dynamics. Independent and collective motions of lipid molecules span a wide range of timescales. In order to understand the lipid bilayer functioning, the correlation between various motions needs to be understood. Molecules with low molecular weight, when placed in the lipid bilayer, may alter membrane properties depending on their location. The effect of two membrane active molecules, ethanol and lidocaine, on the lipid bilayer was investigated in three different timescales by means of dedicated fluorescence techniques. The interfacial water dynamics was measured using ?solvent relaxation technique at picosecond timescale. The lateral lipid molecule mobility along the lipid bilayer surfacewas determined with fluorescence correlation spectroscopy at millisecond timescale, and collective lipid processes, such as spontaneous lipid pore formation, were monitored with fluorescence stopped-flow technique at the timescale of seco

Název v anglickém jazyce

A Multi Time-Scale Approach of the Lipid Bilayer Dynamics

Popis výsledku anglicky

The lipid bilayer is a supramolecular aggregate with complex dynamics. Independent and collective motions of lipid molecules span a wide range of timescales. In order to understand the lipid bilayer functioning, the correlation between various motions needs to be understood. Molecules with low molecular weight, when placed in the lipid bilayer, may alter membrane properties depending on their location. The effect of two membrane active molecules, ethanol and lidocaine, on the lipid bilayer was investigated in three different timescales by means of dedicated fluorescence techniques. The interfacial water dynamics was measured using ?solvent relaxation technique at picosecond timescale. The lateral lipid molecule mobility along the lipid bilayer surfacewas determined with fluorescence correlation spectroscopy at millisecond timescale, and collective lipid processes, such as spontaneous lipid pore formation, were monitored with fluorescence stopped-flow technique at the timescale of seco

Druh

C - Kapitola v odborné knize

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2012

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název knihy nebo sborníku

ADVANCES IN PLANAR LIPID BILAYERS AND LIPOSOMES

ISBN

978-0-12-396533-2

Počet stran výsledku

33

Strana od-do

105-137

Počet stran knihy

249

Název nakladatele

Elsevier

Místo vydání

San Diego

Kód UT WoS kapitoly

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