Organization of Lipids in the Tear Film: A Molecular- Level View

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F14%3A00427289" target="_blank" >RIV/61388955:_____/14:00427289 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/14:00486568

Výsledek na webu

<a href="http://dx.doi.org/10.1371/journal.pone.0092461" target="_blank" >http://dx.doi.org/10.1371/journal.pone.0092461</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1371/journal.pone.0092461" target="_blank" >10.1371/journal.pone.0092461</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Organization of Lipids in the Tear Film: A Molecular- Level View

Popis výsledku v původním jazyce

Biophysical properties of the tear film lipid layer are studied at the molecular level employing coarse grain molecular dynamics (MD) simulations with a realistic model of the human tear film. In this model, polar lipids are chosen to reflect the currentknowledge on the lipidome of the tear film whereas typical Meibomian-origin lipids are included in the thick nonpolar lipids subphase. Simulation conditions mimic those experienced by the real human tear film during blinks. Namely, thermodynamic equilibrium simulations at different lateral compressions are performed to model varying surface pressure, and the dynamics of the system during a blink is studied by non-equilibrium MD simulations. Polar lipids separate their nonpolar counterparts from water by forming a monomolecular layer whereas the non-polar molecules establish a thick outermost lipid layer. Under lateral compression, the polar layer undulates and a sorting of polar lipids occurs. Moreover, formation of three-dimensional a

Název v anglickém jazyce

Organization of Lipids in the Tear Film: A Molecular- Level View

Popis výsledku anglicky

Biophysical properties of the tear film lipid layer are studied at the molecular level employing coarse grain molecular dynamics (MD) simulations with a realistic model of the human tear film. In this model, polar lipids are chosen to reflect the currentknowledge on the lipidome of the tear film whereas typical Meibomian-origin lipids are included in the thick nonpolar lipids subphase. Simulation conditions mimic those experienced by the real human tear film during blinks. Namely, thermodynamic equilibrium simulations at different lateral compressions are performed to model varying surface pressure, and the dynamics of the system during a blink is studied by non-equilibrium MD simulations. Polar lipids separate their nonpolar counterparts from water by forming a monomolecular layer whereas the non-polar molecules establish a thick outermost lipid layer. Under lateral compression, the polar layer undulates and a sorting of polar lipids occurs. Moreover, formation of three-dimensional a

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

PLoS ONE

ISSN

1932-6203

e-ISSN

—

Svazek periodika

9

Číslo periodika v rámci svazku

3

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

—

Kód UT WoS článku

000333352800111

EID výsledku v databázi Scopus

—