Behavior of sphingomyelin and ceramide in a tear film lipid layer model

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00477822" target="_blank" >RIV/61388955:_____/17:00477822 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388963:_____/17:00477753

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.aanat.2016.10.005" target="_blank" >http://dx.doi.org/10.1016/j.aanat.2016.10.005</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.aanat.2016.10.005" target="_blank" >10.1016/j.aanat.2016.10.005</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Behavior of sphingomyelin and ceramide in a tear film lipid layer model

Popis výsledku v původním jazyce

Tear film lipid layer is a complex lipid mixture forming the outermost interface between eye and environment. Its key characteristics, such as surface tension and structural stability, are governed by the presence of polar lipids. The origin of these lipids and exact composition of the mixture are still elusive. We focus on two minor polar lipid components of the tear film lipid later: sphingomyelin and ceramide. By employing coarse grain molecular dynamics in silico simulations accompanied by Langmuir balance experiments we provide molecular-level insight into behavior of these two lipids in a tear film lipid layer model. Sphingomyelin headgroups are significantly exposed at the water-lipids boundary while ceramide molecules are incorporated between other lipids frequently interacting with nonpolar lipids. Even though these two lipids increase surface tension of the film, their molecular-level behavior suggests that they have a stabilizing effect on the tear film lipid layer. (C) 2016 Elsevier GmbH. All rights reserved.

Název v anglickém jazyce

Behavior of sphingomyelin and ceramide in a tear film lipid layer model

Popis výsledku anglicky

Tear film lipid layer is a complex lipid mixture forming the outermost interface between eye and environment. Its key characteristics, such as surface tension and structural stability, are governed by the presence of polar lipids. The origin of these lipids and exact composition of the mixture are still elusive. We focus on two minor polar lipid components of the tear film lipid later: sphingomyelin and ceramide. By employing coarse grain molecular dynamics in silico simulations accompanied by Langmuir balance experiments we provide molecular-level insight into behavior of these two lipids in a tear film lipid layer model. Sphingomyelin headgroups are significantly exposed at the water-lipids boundary while ceramide molecules are incorporated between other lipids frequently interacting with nonpolar lipids. Even though these two lipids increase surface tension of the film, their molecular-level behavior suggests that they have a stabilizing effect on the tear film lipid layer. (C) 2016 Elsevier GmbH. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GA15-14292S" target="_blank" >GA15-14292S: Výzkum lipidového filmu na povrhu oka na molekulární úrovni - simulace molekulární dynamiky a experimenty na modelových lipidových filmech</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Anatomy-Anatomischer Anzeiger

ISSN

0940-9602

e-ISSN

—

Svazek periodika

210

Číslo periodika v rámci svazku

MAR 2017

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

7

Strana od-do

128-134

Kód UT WoS článku

000395610600016

EID výsledku v databázi Scopus

2-s2.0-85007012006