Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F15%3A00452358" target="_blank" >RIV/61388955:_____/15:00452358 - isvavai.cz</a>

Výsledek na webu

<a href="http://dx.doi.org/10.1183/23120541.00044-2015" target="_blank" >http://dx.doi.org/10.1183/23120541.00044-2015</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1183/23120541.00044-2015" target="_blank" >10.1183/23120541.00044-2015</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis

Popis výsledku v původním jazyce

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeruginosa infection.nn233 children with CF who were free from P. aeruginosa infection were followed for 2?years. Their median (interquartile range) age was 8.0 (5.0?12.2)?years. At each study visit, an exhaled breath sample was collected for hydrogen cyanideanalysis. In total, 2055 breath samples were analysed. At the end of the study, the hydrogen cyanide concentrations were compared to the results of routine microbiology surveillance.nnP. aeruginosa was isolated from 71 children during the study with anincidence (95% CI) of 0.19 (0.15?0.23) cases per patient-year. Using a random-effects logistic model, the estimated odds ratio (95% CI) was 3.1 (2.6?3.6), which showed that for a 1-?ppbv increase in exhaled breath hydrogen cyanide, we ex

Název v anglickém jazyce

Exhaled breath hydrogen cyanide as a marker of early Pseudomonas aeruginosa infection in children with cystic fibrosis

Popis výsledku anglicky

Hydrogen cyanide is readily detected in the headspace above Pseudomonas aeruginosa cultures and in the breath of cystic fibrosis (CF) patients with chronic (P. aeruginosa) infection. We investigated if exhaled breath HCN is an early marker of P. aeruginosa infection.nn233 children with CF who were free from P. aeruginosa infection were followed for 2?years. Their median (interquartile range) age was 8.0 (5.0?12.2)?years. At each study visit, an exhaled breath sample was collected for hydrogen cyanideanalysis. In total, 2055 breath samples were analysed. At the end of the study, the hydrogen cyanide concentrations were compared to the results of routine microbiology surveillance.nnP. aeruginosa was isolated from 71 children during the study with anincidence (95% CI) of 0.19 (0.15?0.23) cases per patient-year. Using a random-effects logistic model, the estimated odds ratio (95% CI) was 3.1 (2.6?3.6), which showed that for a 1-?ppbv increase in exhaled breath hydrogen cyanide, we ex

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CF - Fyzikální chemie a teoretická chemie

OECD FORD obor

—

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ERJ Open Research

ISSN

2312-0541

e-ISSN

—

Svazek periodika

1

Číslo periodika v rámci svazku

2015

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

8

Strana od-do

—

Kód UT WoS článku

—

EID výsledku v databázi Scopus

—