Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00471287" target="_blank" >RIV/61388955:_____/17:00471287 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/17:10334979 RIV/65269705:_____/17:00066271 RIV/00064165:_____/17:10334979

Výsledek na webu

<a href="http://dx.doi.org/10.1080/15563650.2016.1250901" target="_blank" >http://dx.doi.org/10.1080/15563650.2016.1250901</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1080/15563650.2016.1250901" target="_blank" >10.1080/15563650.2016.1250901</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning

Popis výsledku v původním jazyce

Context: Acidemia is a marker of prognosis in methanol poisoning, as well as compounding formate-induced cytotoxicity. Prompt correction of acidemia is a key treatment of methanol toxicity and methods to optimize this are poorly defined.nObjective: We studied the efficiency of acidemia correction by intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) in a mass outbreak of methanol poisoning.nMethods: The study was designed as observational cohort study. The mean time for an increase of 1 mmol/L HCO3-, 0.01 unit arterial blood pH, and the total time for correction of HCO3- were determined in IHD- and CRRT-treated patients.nResults: Data were obtained from 18 patients treated with IHD and 13 patients treated with CRRT. At baseline, CRRT group was more acidemic than IHD group (mean arterial pH 6.790.10 versus 7.050.10, p=0.001). No association was found between the rate of acidemia correction and age, weight, serum methanol, lactate, formate, and glucose on admission. The time to HCO3- correction correlated with arterial blood pH (r=-0.511, p=0.003) and creatinine (r=0.415, p=0.020). There was association between the time to HCO3- correction and dialysate/effluent and blood flow rates (r=-0.738, p<0.001 and r=-0.602, p<0.001, correspondingly).nThe mean time for HCO3- to increase by 1mmol/L was 12 +/- 2 min for IHD versus 34 +/- 8 min for CRRT (p<0.001), and the mean time for arterial blood pH to increase 0.01 was 7 +/- 1 mins for IHD versus 11 +/- 4 min for CRRT (p=0.024). The mean increase in HCO3- was 5.67 +/- 0.90 mmol/L/h for IHD versus 2.17 +/- 0.74 mmol/L/h for CRRT (p<0.001).nConclusions: Our study supports the superiority of IHD over CRRT in terms of the rate of acidemia correction.

Název v anglickém jazyce

Efficiency of acidemia correction on intermittent versus continuous hemodialysis in acute methanol poisoning

Popis výsledku anglicky

Context: Acidemia is a marker of prognosis in methanol poisoning, as well as compounding formate-induced cytotoxicity. Prompt correction of acidemia is a key treatment of methanol toxicity and methods to optimize this are poorly defined.nObjective: We studied the efficiency of acidemia correction by intermittent hemodialysis (IHD) and continuous renal replacement therapy (CRRT) in a mass outbreak of methanol poisoning.nMethods: The study was designed as observational cohort study. The mean time for an increase of 1 mmol/L HCO3-, 0.01 unit arterial blood pH, and the total time for correction of HCO3- were determined in IHD- and CRRT-treated patients.nResults: Data were obtained from 18 patients treated with IHD and 13 patients treated with CRRT. At baseline, CRRT group was more acidemic than IHD group (mean arterial pH 6.790.10 versus 7.050.10, p=0.001). No association was found between the rate of acidemia correction and age, weight, serum methanol, lactate, formate, and glucose on admission. The time to HCO3- correction correlated with arterial blood pH (r=-0.511, p=0.003) and creatinine (r=0.415, p=0.020). There was association between the time to HCO3- correction and dialysate/effluent and blood flow rates (r=-0.738, p<0.001 and r=-0.602, p<0.001, correspondingly).nThe mean time for HCO3- to increase by 1mmol/L was 12 +/- 2 min for IHD versus 34 +/- 8 min for CRRT (p<0.001), and the mean time for arterial blood pH to increase 0.01 was 7 +/- 1 mins for IHD versus 11 +/- 4 min for CRRT (p=0.024). The mean increase in HCO3- was 5.67 +/- 0.90 mmol/L/h for IHD versus 2.17 +/- 0.74 mmol/L/h for CRRT (p<0.001).nConclusions: Our study supports the superiority of IHD over CRRT in terms of the rate of acidemia correction.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/NV16-27075A" target="_blank" >NV16-27075A: NEURODEGENERATIVNÍ PROCESY U PACIENTŮ EXPONOVANÝCH METANOLU: PROSPEKTIVNÍ STUDIE PO HROMADNÉ OTRAVĚ METANOLEM V ČESKÉ REPUBLICE V ROCE 2012</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

CLINICAL TOXICOLOGY

ISSN

1556-3650

e-ISSN

—

Svazek periodika

55

Číslo periodika v rámci svazku

2

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

10

Strana od-do

123-132

Kód UT WoS článku

000393890500008

EID výsledku v databázi Scopus

2-s2.0-84994274919