Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F17%3A00476996" target="_blank" >RIV/61388955:_____/17:00476996 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11110/17:10364214 RIV/00064165:_____/17:10364214

Výsledek na webu

<a href="http://dx.doi.org/10.1186/s13613-017-0300-7" target="_blank" >http://dx.doi.org/10.1186/s13613-017-0300-7</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1186/s13613-017-0300-7" target="_blank" >10.1186/s13613-017-0300-7</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Popis výsledku v původním jazyce

Background: Intermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous modalities (CRRT) is unknown. During an outbreak of mass methanol poisoning, we therefore studied the effect of IHD versus CRRT on mortality and the prevalence of visual/central nervous system (CNS) sequelae in survivors.nMethods: The study was designed as prospective observational cohort study. Patients hospitalized with a diagnosis of acute methanol poisoning were identified for the study. Exploratory factor analysis and multivariate logistic regression were applied to determine the effect of ECTR modality on the outcome.nResults: Data were obtained from 41 patients treated with IHD and 40 patients with CRRT. The follow-up time in survivors was two years. Both groups of patients were comparable by age, time to presentation, laboratory data, clinical features, and other treatment applied. The CRRT group was more acidemic (arterial blood pH 6.96 +/- 0.08 vs. 7.17 +/- 0.07, p < 0.001) and more severely poisoned (25/40 vs. 9/41 patients with Glasgow Coma Scale (GCS) <= 8, p < 0.001). The median intensive care unit length of stay (4 (range 1-16) days vs. 4 (1-22) days, p = 0.703) and the number of patients with complications during the treatment (11/41 vs. 13/40 patients, p = 0.576) did not differ between the groups. The mortality was higher in the CRRT group (15/40 vs. 5/41, p = 0.008). The number of survivors without sequelae of poisoning was higher in the IHD group (23/41 vs. 10/40, p = 0.004). There was a significant association of ECTR modality with both mortality and the number of survivors with visual and CNS sequelae of poisoning, but this association was not present after adjustment for arterial blood pH and GCS on admission (all p > 0.05).n

Název v anglickém jazyce

Intermittent versus continuous renal replacement therapy in acute methanol poisoning: comparison of clinical effectiveness in mass poisoning outbreaks

Popis výsledku anglicky

Background: Intermittent hemodialysis (IHD) is the modality of choice in the extracorporeal treatment (ECTR) of acute methanol poisoning. However, the comparative clinical effectiveness of intermittent versus continuous modalities (CRRT) is unknown. During an outbreak of mass methanol poisoning, we therefore studied the effect of IHD versus CRRT on mortality and the prevalence of visual/central nervous system (CNS) sequelae in survivors.nMethods: The study was designed as prospective observational cohort study. Patients hospitalized with a diagnosis of acute methanol poisoning were identified for the study. Exploratory factor analysis and multivariate logistic regression were applied to determine the effect of ECTR modality on the outcome.nResults: Data were obtained from 41 patients treated with IHD and 40 patients with CRRT. The follow-up time in survivors was two years. Both groups of patients were comparable by age, time to presentation, laboratory data, clinical features, and other treatment applied. The CRRT group was more acidemic (arterial blood pH 6.96 +/- 0.08 vs. 7.17 +/- 0.07, p < 0.001) and more severely poisoned (25/40 vs. 9/41 patients with Glasgow Coma Scale (GCS) <= 8, p < 0.001). The median intensive care unit length of stay (4 (range 1-16) days vs. 4 (1-22) days, p = 0.703) and the number of patients with complications during the treatment (11/41 vs. 13/40 patients, p = 0.576) did not differ between the groups. The mortality was higher in the CRRT group (15/40 vs. 5/41, p = 0.008). The number of survivors without sequelae of poisoning was higher in the IHD group (23/41 vs. 10/40, p = 0.004). There was a significant association of ECTR modality with both mortality and the number of survivors with visual and CNS sequelae of poisoning, but this association was not present after adjustment for arterial blood pH and GCS on admission (all p > 0.05).n

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10405 - Electrochemistry (dry cells, batteries, fuel cells, corrosion metals, electrolysis)

Projekt

<a href="/cs/project/NV16-27075A" target="_blank" >NV16-27075A: NEURODEGENERATIVNÍ PROCESY U PACIENTŮ EXPONOVANÝCH METANOLU: PROSPEKTIVNÍ STUDIE PO HROMADNÉ OTRAVĚ METANOLEM V ČESKÉ REPUBLICE V ROCE 2012</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2017

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Annals of Intensive Care

ISSN

2110-5820

e-ISSN

—

Svazek periodika

7

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

DE - Spolková republika Německo

Počet stran výsledku

11

Strana od-do

—

Kód UT WoS článku

000406223100002

EID výsledku v databázi Scopus

2-s2.0-85025449949