A detailed study of the ion chemistry of alkenes focusing on heptenes aimed at their SIFT-MS quantification

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F18%3A00497667" target="_blank" >RIV/61388955:_____/18:00497667 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/18:10388092

Výsledek na webu

<a href="http://dx.doi.org/10.1016/j.ijms.2017.12.004" target="_blank" >http://dx.doi.org/10.1016/j.ijms.2017.12.004</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.ijms.2017.12.004" target="_blank" >10.1016/j.ijms.2017.12.004</a>

Jazyk výsledku

angličtina

Název v původním jazyce

A detailed study of the ion chemistry of alkenes focusing on heptenes aimed at their SIFT-MS quantification

Popis výsledku v původním jazyce

Analyses of trace amounts of alkene vapours present in exhaled breath are becoming important in clinical research related to inflammatory bowel disease, IBD, currently affecting over 1 million patients in the USA and 2.5 million in Europe. Concentrations of alkenes have been previously found to be different in the breath of IBD patients in comparison with healthy controls and are suggested as potential biomarkers of IBD activity. Thus, a detailed selected ion flow tube, SIFT, study of the reactions of H3O+, NO+ and O-2(+center dot) with a homologous series of alkenes (from 1-hexene to 1-decene) and with additional isomers of heptene (trans-2-heptene and a mixture of cis- and trans-3-heptene) has been carried out. The rate coefficients of all primary reactions and product ion branching ratios of the reactions of H3O+ and NO+ ions were obtained, which are necessary for accurate quantification of alkenes by selected ion flow tube mass spectrometry, SIFT-MS. The results of the present study facilitate analyses of these compounds in real breath samples with the ultimate aim of establishing their clinical use. (C) 2017 Elsevier B.V. All rights reserved.

Název v anglickém jazyce

A detailed study of the ion chemistry of alkenes focusing on heptenes aimed at their SIFT-MS quantification

Popis výsledku anglicky

Analyses of trace amounts of alkene vapours present in exhaled breath are becoming important in clinical research related to inflammatory bowel disease, IBD, currently affecting over 1 million patients in the USA and 2.5 million in Europe. Concentrations of alkenes have been previously found to be different in the breath of IBD patients in comparison with healthy controls and are suggested as potential biomarkers of IBD activity. Thus, a detailed selected ion flow tube, SIFT, study of the reactions of H3O+, NO+ and O-2(+center dot) with a homologous series of alkenes (from 1-hexene to 1-decene) and with additional isomers of heptene (trans-2-heptene and a mixture of cis- and trans-3-heptene) has been carried out. The rate coefficients of all primary reactions and product ion branching ratios of the reactions of H3O+ and NO+ ions were obtained, which are necessary for accurate quantification of alkenes by selected ion flow tube mass spectrometry, SIFT-MS. The results of the present study facilitate analyses of these compounds in real breath samples with the ultimate aim of establishing their clinical use. (C) 2017 Elsevier B.V. All rights reserved.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GA13-28882S" target="_blank" >GA13-28882S: Excitace, separace a fragmentace iontů v driftovém poli v SIFT-MS pro okamžitou selektivní kvantifikaci stopových plynů</a><br>

Návaznosti

P - Projekt vyzkumu a vyvoje financovany z verejnych zdroju (s odkazem do CEP)

Rok uplatnění

2018

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

International Journal of Mass Spectrometry

ISSN

1387-3806

e-ISSN

—

Svazek periodika

425

Číslo periodika v rámci svazku

FEB 2018

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

6

Strana od-do

16-21

Kód UT WoS článku

000425743600003

EID výsledku v databázi Scopus

2-s2.0-85039774288