Quantification of volatile metabolites in exhaled breath by selected ion flow tube mass spectrometry, SIFT-MS

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00531420" target="_blank" >RIV/61388955:_____/20:00531420 - isvavai.cz</a>

Výsledek na webu

<a href="http://hdl.handle.net/11104/0310084" target="_blank" >http://hdl.handle.net/11104/0310084</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.clinms.2020.02.001" target="_blank" >10.1016/j.clinms.2020.02.001</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Quantification of volatile metabolites in exhaled breath by selected ion flow tube mass spectrometry, SIFT-MS

Popis výsledku v původním jazyce

Selected ion flow tube mass spectrometry, SIFT-MS, is a non-separative method for direct quantitative analyses of volatile compounds, VOCs, in air and humid breath based on chemical ionization. Selected reagent ions, either H3O+, NO+ or O-2(+) (non-reactive with major components of air), ionize analyte molecules during a defined time in a flow tube by ion-molecule reactions thus producing analyte ions that are characteristic of the neutral analyte VOCs. Concentrations can be calculated in real-time from the ion count rates. Direct on-line analysis of single or multiple breath exhalations or off-line analysis of breath samples collected into bags can be performed. Several volatile breath metabolites have been quantified by SIFT-MS, including ammonia, acetone, hydrogen cyanide, alcohols, pentane, acetic acid, methane, and sulphur compounds. Their potential as biomarkers is discussed. (C) 2020 Published by Elsevier B.V. on behalf of The Association for Mass Spectrometry: Applications to the Clinical Lab (MSACL).

Název v anglickém jazyce

Quantification of volatile metabolites in exhaled breath by selected ion flow tube mass spectrometry, SIFT-MS

Popis výsledku anglicky

Selected ion flow tube mass spectrometry, SIFT-MS, is a non-separative method for direct quantitative analyses of volatile compounds, VOCs, in air and humid breath based on chemical ionization. Selected reagent ions, either H3O+, NO+ or O-2(+) (non-reactive with major components of air), ionize analyte molecules during a defined time in a flow tube by ion-molecule reactions thus producing analyte ions that are characteristic of the neutral analyte VOCs. Concentrations can be calculated in real-time from the ion count rates. Direct on-line analysis of single or multiple breath exhalations or off-line analysis of breath samples collected into bags can be performed. Several volatile breath metabolites have been quantified by SIFT-MS, including ammonia, acetone, hydrogen cyanide, alcohols, pentane, acetic acid, methane, and sulphur compounds. Their potential as biomarkers is discussed. (C) 2020 Published by Elsevier B.V. on behalf of The Association for Mass Spectrometry: Applications to the Clinical Lab (MSACL).

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Clinical mass spectrometry

ISSN

2376-9998

e-ISSN

—

Svazek periodika

16

Číslo periodika v rámci svazku

APR 2020

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

7

Strana od-do

18-24

Kód UT WoS článku

000539276700003

EID výsledku v databázi Scopus

2-s2.0-85079896166