Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00532310" target="_blank" >RIV/61388955:_____/20:00532310 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/61388980:_____/20:00532310 RIV/00216208:11310/20:10405879

Výsledek na webu

<a href="http://hdl.handle.net/11104/0310832" target="_blank" >http://hdl.handle.net/11104/0310832</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acs.langmuir.9b03468" target="_blank" >10.1021/acs.langmuir.9b03468</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties

Popis výsledku v původním jazyce

The transport of a photosensitizer to target biological structures followed by the release of singlet oxygen is a critical step in photodynamic therapy. We compared the (photo)physical properties of polystyrene nanoparticles (TPP@PS) of different sizes and self-assembled poly(ethylene glycol)-b-poly(epsilon-caprolactone) core/shell nanoparticles (TPP@PEG-PCL) with different lengths of copolymer blocks, both suitable for the transport of the tetraphenylporphyrin (TPP) photosensitizer. The singlet oxygen was formed inside both nanoparticles after irradiation with visible light. Its kinetics was controlled by the size of TPP@PS, its lifetime (tau(Delta)) increased with increasing nanoparticle size (from 6.5 to 16 mu s) because of hindered diffusion into the external aqueous environment, where it was quickly deactivated. Accordingly, the prolongation of the singlet oxygen-sensitized delayed fluorescence kinetics was found for TPP@PS of high size. The TPP@PEG-PCL self-assemblies allowed for enhanced oxygen diffusion, and the estimated low values of tau(Delta) approximate to 3.7 mu s were independent of the size of building blocks. The delayed fluorescence in oxygen-free conditions originating from triplet-triplet annihilation indicated a high mobility of TPP in the PCL core in comparison with fixed molecules in the PS matrix. Photooxidation of uric acid revealed the highest efficacy for TPP@PS of small sizes, whereas the largest TPP@PS exhibited the lowest activity, and the efficacy of TPP@PEG-PCL remained independent of the sizes of the building blocks.

Název v anglickém jazyce

Polystyrene and Poly(ethylene glycol)-b-Poly(epsilon-caprolactone) Nanoparticles with Porphyrins: Structure, Size, and Photooxidation Properties

Popis výsledku anglicky

The transport of a photosensitizer to target biological structures followed by the release of singlet oxygen is a critical step in photodynamic therapy. We compared the (photo)physical properties of polystyrene nanoparticles (TPP@PS) of different sizes and self-assembled poly(ethylene glycol)-b-poly(epsilon-caprolactone) core/shell nanoparticles (TPP@PEG-PCL) with different lengths of copolymer blocks, both suitable for the transport of the tetraphenylporphyrin (TPP) photosensitizer. The singlet oxygen was formed inside both nanoparticles after irradiation with visible light. Its kinetics was controlled by the size of TPP@PS, its lifetime (tau(Delta)) increased with increasing nanoparticle size (from 6.5 to 16 mu s) because of hindered diffusion into the external aqueous environment, where it was quickly deactivated. Accordingly, the prolongation of the singlet oxygen-sensitized delayed fluorescence kinetics was found for TPP@PS of high size. The TPP@PEG-PCL self-assemblies allowed for enhanced oxygen diffusion, and the estimated low values of tau(Delta) approximate to 3.7 mu s were independent of the size of building blocks. The delayed fluorescence in oxygen-free conditions originating from triplet-triplet annihilation indicated a high mobility of TPP in the PCL core in comparison with fixed molecules in the PS matrix. Photooxidation of uric acid revealed the highest efficacy for TPP@PS of small sizes, whereas the largest TPP@PS exhibited the lowest activity, and the efficacy of TPP@PEG-PCL remained independent of the sizes of the building blocks.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/GA19-09721S" target="_blank" >GA19-09721S: Fotoaktivní nanovlákenné materiály a nanočástice pro inaktivaci pathogenů</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Langmuir

ISSN

0743-7463

e-ISSN

—

Svazek periodika

36

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

9

Strana od-do

302-310

Kód UT WoS článku

000507721200034

EID výsledku v databázi Scopus

2-s2.0-85077697578