Hepatic tumor cell morphology plasticity under physical constraints in 3D cultures driven by YAP-mTOR axis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F20%3A00537345" target="_blank" >RIV/61388955:_____/20:00537345 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/20:00537345 RIV/00023001:_____/20:00080458 RIV/68378041:_____/20:00553160

Výsledek na webu

<a href="http://hdl.handle.net/11104/0315072" target="_blank" >http://hdl.handle.net/11104/0315072</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.3390/ph13120430" target="_blank" >10.3390/ph13120430</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Hepatic tumor cell morphology plasticity under physical constraints in 3D cultures driven by YAP-mTOR axis

Popis výsledku v původním jazyce

Recent studies undoubtedly show that the mammalian target of rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are important mediators of mechanical cues. The crosstalk between these pathways as well as de-regulation of their signaling has been implicated in multiple tumor types, including liver tumors. Additionally, physical cues from 3D microenvironments have been identified to alter gene expression and di erentiation of di erent cell lineages. However, it remains incompletely understood how physical constraints originated in 3D cultures a ect cell plasticity and what the key mediators are of such process. In this work, we use collagen sca olds as a model of a soft 3D microenvironment to alter cellular size and study the mechanotransduction that regulates that process.

Název v anglickém jazyce

Hepatic tumor cell morphology plasticity under physical constraints in 3D cultures driven by YAP-mTOR axis

Popis výsledku anglicky

Recent studies undoubtedly show that the mammalian target of rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are important mediators of mechanical cues. The crosstalk between these pathways as well as de-regulation of their signaling has been implicated in multiple tumor types, including liver tumors. Additionally, physical cues from 3D microenvironments have been identified to alter gene expression and di erentiation of di erent cell lineages. However, it remains incompletely understood how physical constraints originated in 3D cultures a ect cell plasticity and what the key mediators are of such process. In this work, we use collagen sca olds as a model of a soft 3D microenvironment to alter cellular size and study the mechanotransduction that regulates that process.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

<a href="/cs/project/LTC19040" target="_blank" >LTC19040: Rozvinuté fyzikální metody v studiích hepatotoxicity</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2020

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Pharmaceuticals

ISSN

1424-8247

e-ISSN

—

Svazek periodika

13

Číslo periodika v rámci svazku

12

Stát vydavatele periodika

CH - Švýcarská konfederace

Počet stran výsledku

25

Strana od-do

1-25

Kód UT WoS článku

000602349300001

EID výsledku v databázi Scopus

2-s2.0-85097084397