Mechanical regulation of mitochondrial dynamics and function in a 3D-engineered liver tumor microenvironment

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F68378041%3A_____%2F23%3A00572095" target="_blank" >RIV/68378041:_____/23:00572095 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/68378271:_____/23:00572095 RIV/00023001:_____/23:00083939

Výsledek na webu

<a href="https://hdl.handle.net/11104/0342923" target="_blank" >https://hdl.handle.net/11104/0342923</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1021/acsbiomaterials.2c01518" target="_blank" >10.1021/acsbiomaterials.2c01518</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Mechanical regulation of mitochondrial dynamics and function in a 3D-engineered liver tumor microenvironment

Popis výsledku v původním jazyce

It has become evident that physical stimuli of the cellular microenvironment transmit mechanical cues regulating key cellular functions, such as proliferation, migration, and malignant transformation. Accumulating evidence suggests that tumor cells face variable mechanical stimuli that may induce metabolic rewiring of tumor cells. We therefore designed soft 3D collagen scaffolds mimicking a pathological mechanical environment to decipher how liver tumor cells would adapt their metabolic activity to physical stimuli of the cellular microenvironment. Here, we report that the soft 3D microenvironment upregulates the glycolysis of HepG2 and Alexander cells. Both cell lines adapt their mitochondrial activity and function under growth in the soft 3D microenvironment.

Název v anglickém jazyce

Mechanical regulation of mitochondrial dynamics and function in a 3D-engineered liver tumor microenvironment

Popis výsledku anglicky

It has become evident that physical stimuli of the cellular microenvironment transmit mechanical cues regulating key cellular functions, such as proliferation, migration, and malignant transformation. Accumulating evidence suggests that tumor cells face variable mechanical stimuli that may induce metabolic rewiring of tumor cells. We therefore designed soft 3D collagen scaffolds mimicking a pathological mechanical environment to decipher how liver tumor cells would adapt their metabolic activity to physical stimuli of the cellular microenvironment. Here, we report that the soft 3D microenvironment upregulates the glycolysis of HepG2 and Alexander cells. Both cell lines adapt their mitochondrial activity and function under growth in the soft 3D microenvironment.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10610 - Biophysics

Projekt

<a href="/cs/project/GA22-18634S" target="_blank" >GA22-18634S: Mechanická regulace funkce mitochondrií a glykolýza v buňkách rakoviny jater</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2023

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

ACS BIOMATERIALS SCIENCE & ENGINEERING

ISSN

2373-9878

e-ISSN

2373-9878

Svazek periodika

9

Číslo periodika v rámci svazku

5

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

18

Strana od-do

2408-2425

Kód UT WoS článku

000972147400001

EID výsledku v databázi Scopus

2-s2.0-85151914668