Silver(I), Zinc(II) and Gallium(III) thiophene-2-carboxylates: Synthesis, solution and solid state characterization and bioevaluation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388955%3A_____%2F25%3A00636663" target="_blank" >RIV/61388955:_____/25:00636663 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/00216208:11310/25:10498268

Výsledek na webu

<a href="https://www.sciencedirect.com/science/article/pii/S0162013425001163?via%3Dihub" target="_blank" >https://www.sciencedirect.com/science/article/pii/S0162013425001163?via%3Dihub</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1016/j.jinorgbio.2025.112936" target="_blank" >10.1016/j.jinorgbio.2025.112936</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Silver(I), Zinc(II) and Gallium(III) thiophene-2-carboxylates: Synthesis, solution and solid state characterization and bioevaluation

Popis výsledku v původním jazyce

Three 2-thiophenecarboxylate (Tio2c) complexes with different central atoms Ag(I), Zn(II) and Ga(III), [Ag(Tio2c)]2 (AgTio2c), {[Zn2(Tio2c)4]2}n (ZnTio2c) and [Ga(Tio2c)3]·H2O (GaTio2c), were synthesized and elemental, spectral and thermal analyses were used for their characterization. The AgTio2c and ZnTio2c single crystal structures confirmed the most common bidentate bridging coordination mode with typical strong argentophilic interactions in the case of AgTio2c complex. Complexes' stability in biological test stock solution were confirmed by 1H NMR spectroscopy. Potentiometric data analysis by BSTAC program resulted in the determination of the stability constants of four complex species, [Zn(Tio2c)]+ (log β110 = 2.06 ± 0.04), [Zn(Tio2c)(OH)] (log β11–1 = −5.0 ± 0.1), [Zn(Tio2c)(OH)2]− (log β11–2 = −12.9 ± 0.4) and [Zn(Tio2c)2(OH)2]2− (log β12–2 = −8.54 ± 0.04) with low abundance in aqueous solution. Theoretical estimation of the complex species in aqueous solution indicates a rather monodentate Tio2c coordination mode in the [Zn(Tio2c)]+ species, while the hydroxido complex species prefer a rather bidentate O,Oʼ-bond of the carboxylate. Antimicrobial and anticancer bioassays clearly confirmed the highest biological activity (toxicity) of the AgTio2c complex. The activity of ZnTio2c was slightly higher (or the same) compared to GaTio2c. The HSA (human serum albumin) binding behaviour of the AgTio2c, ZnTio2c and GaTio2c complexes was investigated using fluorescence spectroscopy and results revealed that the calculated Kb values were in the order of 104 M−1.

Název v anglickém jazyce

Silver(I), Zinc(II) and Gallium(III) thiophene-2-carboxylates: Synthesis, solution and solid state characterization and bioevaluation

Popis výsledku anglicky

Three 2-thiophenecarboxylate (Tio2c) complexes with different central atoms Ag(I), Zn(II) and Ga(III), [Ag(Tio2c)]2 (AgTio2c), {[Zn2(Tio2c)4]2}n (ZnTio2c) and [Ga(Tio2c)3]·H2O (GaTio2c), were synthesized and elemental, spectral and thermal analyses were used for their characterization. The AgTio2c and ZnTio2c single crystal structures confirmed the most common bidentate bridging coordination mode with typical strong argentophilic interactions in the case of AgTio2c complex. Complexes' stability in biological test stock solution were confirmed by 1H NMR spectroscopy. Potentiometric data analysis by BSTAC program resulted in the determination of the stability constants of four complex species, [Zn(Tio2c)]+ (log β110 = 2.06 ± 0.04), [Zn(Tio2c)(OH)] (log β11–1 = −5.0 ± 0.1), [Zn(Tio2c)(OH)2]− (log β11–2 = −12.9 ± 0.4) and [Zn(Tio2c)2(OH)2]2− (log β12–2 = −8.54 ± 0.04) with low abundance in aqueous solution. Theoretical estimation of the complex species in aqueous solution indicates a rather monodentate Tio2c coordination mode in the [Zn(Tio2c)]+ species, while the hydroxido complex species prefer a rather bidentate O,Oʼ-bond of the carboxylate. Antimicrobial and anticancer bioassays clearly confirmed the highest biological activity (toxicity) of the AgTio2c complex. The activity of ZnTio2c was slightly higher (or the same) compared to GaTio2c. The HSA (human serum albumin) binding behaviour of the AgTio2c, ZnTio2c and GaTio2c complexes was investigated using fluorescence spectroscopy and results revealed that the calculated Kb values were in the order of 104 M−1.

Druh

J_imp - Článek v periodiku v databázi Web of Science

CEP obor

—

OECD FORD obor

10403 - Physical chemistry

Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2025

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Inorganic Biochemistry

ISSN

0162-0134

e-ISSN

1873-3344

Svazek periodika

270

Číslo periodika v rámci svazku

SEP 2025

Stát vydavatele periodika

NL - Nizozemsko

Počet stran výsledku

13

Strana od-do

112936

Kód UT WoS článku

001487098600001

EID výsledku v databázi Scopus

2-s2.0-105004034423