Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F10%3A00342537" target="_blank" >RIV/61388963:_____/10:00342537 - isvavai.cz</a>

Výsledek na webu

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DOI - Digital Object Identifier

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Jazyk výsledku

angličtina

Název v původním jazyce

Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation

Popis výsledku v původním jazyce

The aim of this study was to determine the impact of two anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons located in the arcuate (ARC) and ventromedial (VMN) nucleiand hypocretin (Hcrt) synthesizing neurons located in the lateral hypothalamic area (LHA). After overnight starvation, male C57Bl/6 mice received in the morning saline (SAL), CCK (4 ?g/kg, i.p.), CART peptide (0.1 ?g/mice, i.c.v.) or CCK followed 5 minutes later by CART peptide. After 60 min, the presence of Fos or Fos-Hcrt immunostainings signalized the effect of treatments on the cell activity in ARC and VMN, as well as Hcrt cell activity in the LHA. The results indicate that CCK may modify the effectof CART peptide and thus substantially influence the activity of neurons in the hypothalamic structures involved in the food intake regulation.

Název v anglickém jazyce

Effect of anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons in hypothalamic structures of C57Bl/6 mice involved in the food intake regulation

Popis výsledku anglicky

The aim of this study was to determine the impact of two anorexinergic peptides, cholecystokinin (CCK) and cocaine and amphetamine regulated transcript (CART) peptide, on the activity of neurons located in the arcuate (ARC) and ventromedial (VMN) nucleiand hypocretin (Hcrt) synthesizing neurons located in the lateral hypothalamic area (LHA). After overnight starvation, male C57Bl/6 mice received in the morning saline (SAL), CCK (4 ?g/kg, i.p.), CART peptide (0.1 ?g/mice, i.c.v.) or CCK followed 5 minutes later by CART peptide. After 60 min, the presence of Fos or Fos-Hcrt immunostainings signalized the effect of treatments on the cell activity in ARC and VMN, as well as Hcrt cell activity in the LHA. The results indicate that CCK may modify the effectof CART peptide and thus substantially influence the activity of neurons in the hypothalamic structures involved in the food intake regulation.

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CE - Biochemie

OECD FORD obor

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Projekt

<a href="/cs/project/GA303%2F05%2F0614" target="_blank" >GA303/05/0614: Centrální a periferní účinky CART (cocaine and amphetamine regulated transcript ) související s příjmem potravy</a><br>

Návaznosti

Z - Vyzkumny zamer (s odkazem do CEZ)

Rok uplatnění

2010

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Peptides

ISSN

0196-9781

e-ISSN

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Svazek periodika

31

Číslo periodika v rámci svazku

1

Stát vydavatele periodika

US - Spojené státy americké

Počet stran výsledku

6

Strana od-do

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Kód UT WoS článku

000274375500019

EID výsledku v databázi Scopus

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