Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00396383" target="_blank" >RIV/61388963:_____/13:00396383 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68378041:_____/13:00396383 RIV/00216208:11140/13:10138966
Výsledek na webu
<a href="http://dx.doi.org/10.1016/j.fitote.2013.05.025" target="_blank" >http://dx.doi.org/10.1016/j.fitote.2013.05.025</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1016/j.fitote.2013.05.025" target="_blank" >10.1016/j.fitote.2013.05.025</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties
Popis výsledku v původním jazyce
Three new and five known sesquiterpene lactones were isolated from the roots of Laser trilobum (L.) Borkh. Chemical identity of the known compounds and structural analysis of the new ones were determined by HR MS and NMR spectroscopy. The two new sesquiterpene lactones: 2-acetoxytrilobolide and 2-hydroxy-10-deacetyltrilobolide belong to the guaianolide type, and the third one, eudeslaserolide, to the biogenetically related eudesmanolide type. Both types, together with their biogenetic precursor of germacranolide type (laserolide) are present in L. trilobum, as well as in the related Laserpitium species. Purposefully selected set of these native sesquiterpene lactones was tested for specific immunobiological properties. The obtained results demonstratethat trilobolide and its acetoxy analog are strong activators of cytokine secretion. On the contrary, the other L. trilobum and Laserpitium siler constituents are only very mild activators, or even inhibitors of the cytokine and nitric ox
Název v anglickém jazyce
Trilobolide and related sesquiterpene lactones from Laser trilobum possessing immunobiological properties
Popis výsledku anglicky
Three new and five known sesquiterpene lactones were isolated from the roots of Laser trilobum (L.) Borkh. Chemical identity of the known compounds and structural analysis of the new ones were determined by HR MS and NMR spectroscopy. The two new sesquiterpene lactones: 2-acetoxytrilobolide and 2-hydroxy-10-deacetyltrilobolide belong to the guaianolide type, and the third one, eudeslaserolide, to the biogenetically related eudesmanolide type. Both types, together with their biogenetic precursor of germacranolide type (laserolide) are present in L. trilobum, as well as in the related Laserpitium species. Purposefully selected set of these native sesquiterpene lactones was tested for specific immunobiological properties. The obtained results demonstratethat trilobolide and its acetoxy analog are strong activators of cytokine secretion. On the contrary, the other L. trilobum and Laserpitium siler constituents are only very mild activators, or even inhibitors of the cytokine and nitric ox
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
CC - Organická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
<a href="/cs/project/GA305%2F07%2F0061" target="_blank" >GA305/07/0061: Imunofarmakologický potenciál inhibitorů endoplazmatické Ca(2+)-ATPasy (SERCA)</a><br>
Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Fitoterapia
ISSN
0367-326X
e-ISSN
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Svazek periodika
89
Číslo periodika v rámci svazku
September
Stát vydavatele periodika
IT - Italská republika
Počet stran výsledku
10
Strana od-do
157-166
Kód UT WoS článku
000323856500017
EID výsledku v databázi Scopus
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