The Effects of Pterostilbene on Neutrophil Activity in Experimental Model of Arthritis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F13%3A00399813" target="_blank" >RIV/61388963:_____/13:00399813 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/68081707:_____/13:00399813
Výsledek na webu
<a href="http://dx.doi.org/10.1155/2013/106041" target="_blank" >http://dx.doi.org/10.1155/2013/106041</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1155/2013/106041" target="_blank" >10.1155/2013/106041</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
The Effects of Pterostilbene on Neutrophil Activity in Experimental Model of Arthritis
Popis výsledku v původním jazyce
It has been demonstrated that pterostilbene inhibits reactive oxygen species production in neutrophils in vitro. However, little is known about its effects on neutrophils during inflammation in vivo. In this study, the effect of pterostilbene on neutrophil activity was investigated in experimental arthritis model. Lewis rats were injected by a single intradermal injection of heat-killed Mycobacterium butyricum in Freund's adjuvant to develop arthritis. Another group of arthritic animals received pterostilbene 30mg/kg, daily, p.o. The number and activity of neutrophils in blood were measured on a weekly basis during the whole experiment. Moreover, the total radical trapping potential in plasma was measured at the end of the experiment. In the pterostilbene treated arthritic group, the treatment significantly lowered the number of neutrophils in blood on days 14 and 21 without significant downregulation of neutrophil oxidative burst. Pterostilbene nonsignificantly increased total radical
Název v anglickém jazyce
The Effects of Pterostilbene on Neutrophil Activity in Experimental Model of Arthritis
Popis výsledku anglicky
It has been demonstrated that pterostilbene inhibits reactive oxygen species production in neutrophils in vitro. However, little is known about its effects on neutrophils during inflammation in vivo. In this study, the effect of pterostilbene on neutrophil activity was investigated in experimental arthritis model. Lewis rats were injected by a single intradermal injection of heat-killed Mycobacterium butyricum in Freund's adjuvant to develop arthritis. Another group of arthritic animals received pterostilbene 30mg/kg, daily, p.o. The number and activity of neutrophils in blood were measured on a weekly basis during the whole experiment. Moreover, the total radical trapping potential in plasma was measured at the end of the experiment. In the pterostilbene treated arthritic group, the treatment significantly lowered the number of neutrophils in blood on days 14 and 21 without significant downregulation of neutrophil oxidative burst. Pterostilbene nonsignificantly increased total radical
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
EI - Biotechnologie a bionika
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2013
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
BIOMED RESEARCH INTERNATIONAL
ISSN
2314-6133
e-ISSN
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Svazek periodika
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Číslo periodika v rámci svazku
106041
Stát vydavatele periodika
US - Spojené státy americké
Počet stran výsledku
7
Strana od-do
"106041/1"-"106041/7"
Kód UT WoS článku
000325580600001
EID výsledku v databázi Scopus
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