N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00435700" target="_blank" >RIV/61388963:_____/14:00435700 - isvavai.cz</a>

Nalezeny alternativní kódy

RIV/60461373:22330/14:43898163

Výsledek na webu

<a href="http://dx.doi.org/10.1111/fcp.12085" target="_blank" >http://dx.doi.org/10.1111/fcp.12085</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1111/fcp.12085" target="_blank" >10.1111/fcp.12085</a>

Jazyk výsledku

angličtina

Název v původním jazyce

N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis

Popis výsledku v původním jazyce

Many of disease-modifying anti-rheumatic drugs often have side effects at high doses and/or during long-term administration. Increased efficacy without increased toxicity is expected for combination therapy of rheumatoid arthritis (RA). The aim of the study was to examine the effect of N-feruloylserotonin (N-f-5HT) and methotrexate (MTX) in monotherapy and in combination therapy on disease progression and inflammation in arthritic rats. Adjuvant arthritis was induced by intradermal injection of Mycobacteriumbutyricum in incomplete Freunds adjuvant in Lewis rats. The experiment included healthy animals, arthritic animals without any drug administration, arthritic animals with administration of N-f-5HT in the oral daily dose of 15mg/kg b.w., arthritic animals with administration of MTX in the oral dose of 0.3mg/kg b.w. twice a week and arthritic animals treated with the combination of N-f-5HT and MTX. N-f-5HT in monotherapy reduced only activation of NF-B and did not have any significant

Název v anglickém jazyce

N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis

Popis výsledku anglicky

Many of disease-modifying anti-rheumatic drugs often have side effects at high doses and/or during long-term administration. Increased efficacy without increased toxicity is expected for combination therapy of rheumatoid arthritis (RA). The aim of the study was to examine the effect of N-feruloylserotonin (N-f-5HT) and methotrexate (MTX) in monotherapy and in combination therapy on disease progression and inflammation in arthritic rats. Adjuvant arthritis was induced by intradermal injection of Mycobacteriumbutyricum in incomplete Freunds adjuvant in Lewis rats. The experiment included healthy animals, arthritic animals without any drug administration, arthritic animals with administration of N-f-5HT in the oral daily dose of 15mg/kg b.w., arthritic animals with administration of MTX in the oral dose of 0.3mg/kg b.w. twice a week and arthritic animals treated with the combination of N-f-5HT and MTX. N-f-5HT in monotherapy reduced only activation of NF-B and did not have any significant

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

FR - Farmakologie a lékárnická chemie

OECD FORD obor

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Projekt

—

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2014

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Fundamental and Clinical Pharmacology

ISSN

0767-3981

e-ISSN

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Svazek periodika

28

Číslo periodika v rámci svazku

6

Stát vydavatele periodika

FR - Francouzská republika

Počet stran výsledku

11

Strana od-do

616-626

Kód UT WoS článku

000345305000003

EID výsledku v databázi Scopus

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