N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis
Identifikátory výsledku
Kód výsledku v IS VaVaI
<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F14%3A00435700" target="_blank" >RIV/61388963:_____/14:00435700 - isvavai.cz</a>
Nalezeny alternativní kódy
RIV/60461373:22330/14:43898163
Výsledek na webu
<a href="http://dx.doi.org/10.1111/fcp.12085" target="_blank" >http://dx.doi.org/10.1111/fcp.12085</a>
DOI - Digital Object Identifier
<a href="http://dx.doi.org/10.1111/fcp.12085" target="_blank" >10.1111/fcp.12085</a>
Alternativní jazyky
Jazyk výsledku
angličtina
Název v původním jazyce
N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis
Popis výsledku v původním jazyce
Many of disease-modifying anti-rheumatic drugs often have side effects at high doses and/or during long-term administration. Increased efficacy without increased toxicity is expected for combination therapy of rheumatoid arthritis (RA). The aim of the study was to examine the effect of N-feruloylserotonin (N-f-5HT) and methotrexate (MTX) in monotherapy and in combination therapy on disease progression and inflammation in arthritic rats. Adjuvant arthritis was induced by intradermal injection of Mycobacteriumbutyricum in incomplete Freunds adjuvant in Lewis rats. The experiment included healthy animals, arthritic animals without any drug administration, arthritic animals with administration of N-f-5HT in the oral daily dose of 15mg/kg b.w., arthritic animals with administration of MTX in the oral dose of 0.3mg/kg b.w. twice a week and arthritic animals treated with the combination of N-f-5HT and MTX. N-f-5HT in monotherapy reduced only activation of NF-B and did not have any significant
Název v anglickém jazyce
N-feruloylserotonin in preventive combination therapy with methotrexate reduced inflammation in adjuvant arthritis
Popis výsledku anglicky
Many of disease-modifying anti-rheumatic drugs often have side effects at high doses and/or during long-term administration. Increased efficacy without increased toxicity is expected for combination therapy of rheumatoid arthritis (RA). The aim of the study was to examine the effect of N-feruloylserotonin (N-f-5HT) and methotrexate (MTX) in monotherapy and in combination therapy on disease progression and inflammation in arthritic rats. Adjuvant arthritis was induced by intradermal injection of Mycobacteriumbutyricum in incomplete Freunds adjuvant in Lewis rats. The experiment included healthy animals, arthritic animals without any drug administration, arthritic animals with administration of N-f-5HT in the oral daily dose of 15mg/kg b.w., arthritic animals with administration of MTX in the oral dose of 0.3mg/kg b.w. twice a week and arthritic animals treated with the combination of N-f-5HT and MTX. N-f-5HT in monotherapy reduced only activation of NF-B and did not have any significant
Klasifikace
Druh
J<sub>x</sub> - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)
CEP obor
FR - Farmakologie a lékárnická chemie
OECD FORD obor
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Návaznosti výsledku
Projekt
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Návaznosti
I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace
Ostatní
Rok uplatnění
2014
Kód důvěrnosti údajů
S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů
Údaje specifické pro druh výsledku
Název periodika
Fundamental and Clinical Pharmacology
ISSN
0767-3981
e-ISSN
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Svazek periodika
28
Číslo periodika v rámci svazku
6
Stát vydavatele periodika
FR - Francouzská republika
Počet stran výsledku
11
Strana od-do
616-626
Kód UT WoS článku
000345305000003
EID výsledku v databázi Scopus
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