Carborane-beta-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Kód výsledku v IS VaVaI

<a href="https://www.isvavai.cz/riv?ss=detail&h=RIV%2F61388963%3A_____%2F15%3A00443140" target="_blank" >RIV/61388963:_____/15:00443140 - isvavai.cz</a>

Výsledek na webu

<a href="http://pubs.rsc.org/en/content/articlepdf/2015/tb/c4tb01489h" target="_blank" >http://pubs.rsc.org/en/content/articlepdf/2015/tb/c4tb01489h</a>

DOI - Digital Object Identifier

<a href="http://dx.doi.org/10.1039/c4tb01489h" target="_blank" >10.1039/c4tb01489h</a>

Jazyk výsledku

angličtina

Název v původním jazyce

Carborane-beta-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Popis výsledku v původním jazyce

Supramolecular chemistry provides an attractive entry to generate dynamic and well-controlled bioactive surfaces. Novel host-guest systems are urgently needed to provide a broader affinity and applicability portfolio. A synthetic strategy to carborane-peptide bioconjugates was therefore developed to provide an entry to monovalent supramolecular functionalization of beta-cyclodextrin coated surfaces. The beta-cyclodextrin carborane-cRGD surfaces are formed efficiently and with high affinity as demonstrated by IR-RAS, WCA, and QCM-D, compare favourable to existing bio-active host-guest surface assemblies, and display an efficient bioactivity, as illustrated by a strong functional effect of the supramolecular system on the cell adhesion and spreading properties. Cells seeded on the supramolecular surface displaying bioactive peptide epitopes exhibited a more elongated morphology, focal adhesions, and stronger cell adhesion compared to control surfaces. This highlights the macroscopic func

Název v anglickém jazyce

Carborane-beta-cyclodextrin complexes as a supramolecular connector for bioactive surfaces

Popis výsledku anglicky

Supramolecular chemistry provides an attractive entry to generate dynamic and well-controlled bioactive surfaces. Novel host-guest systems are urgently needed to provide a broader affinity and applicability portfolio. A synthetic strategy to carborane-peptide bioconjugates was therefore developed to provide an entry to monovalent supramolecular functionalization of beta-cyclodextrin coated surfaces. The beta-cyclodextrin carborane-cRGD surfaces are formed efficiently and with high affinity as demonstrated by IR-RAS, WCA, and QCM-D, compare favourable to existing bio-active host-guest surface assemblies, and display an efficient bioactivity, as illustrated by a strong functional effect of the supramolecular system on the cell adhesion and spreading properties. Cells seeded on the supramolecular surface displaying bioactive peptide epitopes exhibited a more elongated morphology, focal adhesions, and stronger cell adhesion compared to control surfaces. This highlights the macroscopic func

Druh

J_x - Nezařazeno - Článek v odborném periodiku (Jimp, Jsc a Jost)

CEP obor

CD - Makromolekulární chemie

OECD FORD obor

—

Projekt

<a href="/cs/project/LH11027" target="_blank" >LH11027: Biokompatibilizace a cílení nanočástic pro diagnostické a terapeutické účely</a><br>

Návaznosti

I - Institucionalni podpora na dlouhodoby koncepcni rozvoj vyzkumne organizace

Rok uplatnění

2015

Kód důvěrnosti údajů

S - Úplné a pravdivé údaje o projektu nepodléhají ochraně podle zvláštních právních předpisů

Název periodika

Journal of Materials Chemistry B

ISSN

2050-750X

e-ISSN

—

Svazek periodika

3

Číslo periodika v rámci svazku

4

Stát vydavatele periodika

GB - Spojené království Velké Británie a Severního Irska

Počet stran výsledku

7

Strana od-do

539-545

Kód UT WoS článku

000346906500002

EID výsledku v databázi Scopus

2-s2.0-84919897986